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diagnosis differential hepatology clinical management algorithm causes pocus ultrasound pathophysiology treatment physicalexam hematology hepatic radiology nephrology video gastroenterology pharmacology syndrome
Cholestatic Liver Disease: Primary Biliary Cirrhosis vs Primary Sclerosing Cholangitis #pathophysiology #pbc #psc #hepatology #comparison
Cholestatic Liver ... Primary Biliary Cirrhosis
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
RNA • R < 2: Cholestasis ... Obstruction: Cholestasis ... epithelia - Cholestasis ... ALT: typical of cholestatic ... hepatitis: < 1 • Cirrhosis
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
poisoning, ETOH Cholestatic ... elevation Labs in Cholestatic ... epithelia: - Cholestasis ... ALT: typical of cholestatic ... hepatitis: < 1 • Cirrhosis
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... def, Wilson's, Cholestatic ... dz Cholestatic ... Congenital, Others, Cirrhosis
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
Primary Biliary Cirrhosis ... bile ducts causes cholestasis ... → Cirrhosis/Liver ... or higher • Liver ... , Intrahepatic cholestasis
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... • Others • Cholestatic ... Infiltrative • Cirrhosis
Clinical Examination for Liver and Biliary Diseases 1) Hands: Clubbing, Dupuytren's contracture, Leuconychia, Bruising, Flapping tremor (hepatic
Examination for Liver ... with chronic, cholestasis ... #physicalexam #cirrhosis ... #liver #disease
The 6 C’s of Primary Sclerosing Cholangitis (PSC) PSC is a chronic, cholestatic, immune-mediated disease characterized by
is a chronic, cholestatic ... • CIRRHOSIS - ... Progression to cirrhosis ... indications for liver ... and end-stage liver
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury Hepatocellular Liver Injury • AST/ALT elevation
Liver Enzymes (LFTs ... Hepatocellular and Cholestatic ... Hepatocellular or Cholestatic ... R ≤ 2 = Cholestatic ... Hepatocellular #Cholestatic
Classification of Jaundice Unconjugated hyperbilirubinemia (predominantly indirect bilirubin) • Increased bilirubin production (eg, hemolytic anemias, hemolytic reactions,
• Hereditary Cholestatic ... of intrahepatic cholestasis ... hepatitis, hepatic cirrhosis ... ) Intrahepatic cholestasis ... drugs, biliary cirrhosis
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