792 results
Cholestatic Liver Disease: Primary Biliary Cirrhosis vs Primary Sclerosing Cholangitis

#pathophysiology #pbc #psc #hepatology #comparison
Cholestatic Liver ... Cholangitis #pathophysiology
Primary Biliary Cirrhosis - Pathophysiology
Environmental Risk Factors: Geographic location, Smoking, Microbial triggers, Xenobiotics, Nail polish
Epigentics Risk
Biliary Cirrhosis - Pathophysiology ... relative with PBC Pathophysiology ... biliary fibrosis - Cholestasis ... Biliary #Cirrhosis #Pathophysiology
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
65 years PBC Pathophysiology ... bile ducts causes cholestasis ... , Intrahepatic cholestasis ... , Drug-induced cholestasis
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
Pregnancy (AFLP) Pathophysiology ... , Intrahepatic Cholestasis ... diagnosis #management #pathophysiology
Classification of Jaundice
Unconjugated hyperbilirubinemia (predominantly indirect bilirubin)
 • Increased bilirubin production (eg, hemolytic anemias, hemolytic reactions,
• Hereditary Cholestatic ... familial intrahepatic cholestasis ... of intrahepatic cholestasis ... ) Intrahepatic cholestasis ... or intrahepatic cholestasis
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury
Hepatocellular Liver Injury
 • AST/ALT elevation
Hepatocellular and Cholestatic ... Hepatocellular or Cholestatic ... R ≤ 2 = Cholestatic ... Hepatocellular #Cholestatic
Evaluation abnormal liver tests in pregnancy
- Cholestatic Pattern
- Hepatocellular Pattern

#LFTs #transaminits #pregnancy #obgyn #obstetrics #hepatology #diagnosis
in pregnancy - Cholestatic
Liver Function Test (LFTs) Elevation
AST - Cardiac and skeletal muscle, kidney, brain
ALT - More specific for
ALT ≥ 3x ULN Cholestatic ... pattern ≤2: Cholestatic
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
RNA • R < 2: Cholestasis ... Obstruction: Cholestasis ... epithelia - Cholestasis ... ALT: typical of cholestatic
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
poisoning, ETOH Cholestatic ... elevation Labs in Cholestatic ... epithelia: - Cholestasis ... ALT: typical of cholestatic