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Cholestatic Liver Disease: Primary Biliary Cirrhosis vs Primary Sclerosing Cholangitis #pathophysiology #pbc #psc #hepatology #comparison
Cholestatic Liver ... Cholangitis #pathophysiology
Classification of Jaundice Unconjugated hyperbilirubinemia (predominantly indirect bilirubin) • Increased bilirubin production (eg, hemolytic anemias, hemolytic reactions,
• Hereditary Cholestatic ... familial intrahepatic cholestasis ... of intrahepatic cholestasis ... ) Intrahepatic cholestasis ... or intrahepatic cholestasis
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury Hepatocellular Liver Injury • AST/ALT elevation
Hepatocellular and Cholestatic ... Hepatocellular or Cholestatic ... R ≤ 2 = Cholestatic ... Hepatocellular #Cholestatic
Evaluation abnormal liver tests in pregnancy - Cholestatic Pattern - Hepatocellular Pattern #LFTs #transaminits #pregnancy #obgyn #obstetrics #hepatology #diagnosis
in pregnancy - Cholestatic
Primary Biliary Cirrhosis - Pathophysiology Environmental Risk Factors: Geographic location, Smoking, Microbial triggers, Xenobiotics, Nail polish Epigentics Risk
Biliary Cirrhosis - Pathophysiology ... relative with PBC Pathophysiology ... biliary fibrosis - Cholestasis ... Biliary #Cirrhosis #Pathophysiology
Jaundice - Pathophysiology and Causes - Amy Chung, MD, MSc @AmyChung #Jaundice #Pathophysiology #Differential #Unconjugated #Causes #Diagnosis
Jaundice - Pathophysiology ... Amy Chung, MD, MSc ... #Jaundice #Pathophysiology
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
ALT ≥ 3x ULN Cholestatic ... pattern ≤2: Cholestatic
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
RNA • R < 2: Cholestasis ... Obstruction: Cholestasis ... epithelia - Cholestasis ... ALT: typical of cholestatic
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
poisoning, ETOH Cholestatic ... elevation Labs in Cholestatic ... epithelia: - Cholestasis ... ALT: typical of cholestatic
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
def, Wilson's, Cholestatic ... dz Cholestatic
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