35 results
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Elevated Liver Enzymes ... - Differential ... • Cholestatic disease ... Infiltrative • Cirrhosis ... • Others #LFTs
Common Etiologies of Cirrhosis

Inflammation

 - Hepatitis B (15 percent)

 - Hepatitis C (47 percent)

 - Schistosomiasis
Etiologies of Cirrhosis ... Nonalcoholic fatty liver ... (Budd-Chiari syndrome ... #Diagnosis #Differential ... #Hepatology #Cirrhosis
Ascites - Differential Diagnosis
Chronic liver disease (cirrhosis or chronic hepatitis) - 80%
Underlying malignancy - 10%
Congestive heart
Ascites - Differential ... Diagnosis Chronic liver ... disease (cirrhosis ... Fitz-Hugh-Curtis syndrome ... #Diagnosis #hepatology
Hepatomegaly - Differential Diagnosis Algorithm
Malignant
 • Primary Carcinoma
 • Metastases
 • Lymphoma
 • Leukemia
 • Polycythemia
Diagnosis Algorithm ... Non-Malignant • Fatty Liver ... Hemochromatosis • Wilson's Disease ... • Budd-Chiari Syndrome ... Primary Biliary Cirrhosis
Diagnosis of ascites according to the serum ascites albumin gradient (SAAG)
SAAG ≥ 1.1:
 - Ascitic protein
protein ≤ 2.5 g/dL: Cirrhosis ... , Massive liver ... albumin #gradient #hepatology ... #differential # ... diagnosis #algorithm
Causes of Ascites - Differential Diagnosis Algorithm
Portal Hypertension - Prehepatic:
 • Portal vein thrombosis
 • Splenic
Diagnosis Algorithm ... - Hepatic: • Cirrhosis ... • Infiltrative disease ... • Acute liver ... #Hepatology #causes
Portal Hypertension - Differential Diagnosis
Portal Pressure = the pressure difference between the pressure in the portal
Hypertension - Differential ... and hepatorenal syndrome ... • Budd Chiari syndrome ... sarcoidosis) • Liver ... Veno-occlusive disease
Causes of Portal Hypertension According to Site of Vascular Obstruction
1) Prehepatic pre-sinusoidal: Portal vein thrombosis due
or secondary to cirrhosis ... , Polycystic liver ... post-sinusoidal: Budd-Chiari syndrome ... portalhypertension #phtn #differential ... diagnosis #causes #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
Hemochromatosis, Wilson's disease ... HELLP, Celiac disease ... #Diagnosis #hepatology ... #algorithm #Transaminitis ... #LFTs #hepatitis
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI)

DILI Types:
 • Intrinsic - predictable, dose dependent
Chronic - ongoing ↑ LFTs ... disease 6-9 mo ... Idiosyncratic #differential ... gastroenterology #algorithm ... gastroenterology #hepatology