43 results
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI)

DILI Types:
 • Intrinsic - predictable, dose dependent
Chronic - ongoing ↑ LFTs ... disease 6-9 mo ... Idiosyncratic #differential ... #algorithm #gastroenterology ... #hepatology
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes
== Primary Skin Lesions ==
Macules /
Pruritus - Generalized ... Differential Diagnosis ... Myelodisplastic syndrome ... #dermatology #Differential ... #Diagnosis #Algorithm
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Elevated Liver Enzymes ... Diagnosis Algorithm ... • Cholestatic disease ... • Others #LFTs ... Diagnosis #Algorithm
Ascites - Differential Diagnosis
Chronic liver disease (cirrhosis or chronic hepatitis) - 80%
Underlying malignancy - 10%
Congestive heart
Ascites - Differential ... Diagnosis Chronic ... liver disease ( ... Fitz-Hugh-Curtis syndrome ... #Diagnosis #hepatology
Common Etiologies of Cirrhosis

Inflammation

 - Hepatitis B (15 percent)

 - Hepatitis C (47 percent)

 - Schistosomiasis
Nonalcoholic fatty liver ... (Budd-Chiari syndrome ... 14 percent) #Diagnosis ... #Differential # ... Hepatology #Cirrhosis
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines

ACLF = possibly reversible condition in those with CLD (± cirrhosis)
those with CLD (± cirrhosis ... months without treatment ... disease, liver ... #Hepatology #gastroenterology ... #management #diagnosis
Hepatomegaly - Differential Diagnosis Algorithm
Malignant
 • Primary Carcinoma
 • Metastases
 • Lymphoma
 • Leukemia
 • Polycythemia
Diagnosis Algorithm ... Non-Malignant • Fatty Liver ... • Budd-Chiari Syndrome ... Primary Biliary Cirrhosis ... #Diagnosis #Algorithm
Diagnosis of ascites according to the serum ascites albumin gradient (SAAG)
SAAG ≥ 1.1:
 - Ascitic protein
Diagnosis of ascites ... protein ≤ 2.5 g/dL: Cirrhosis ... , Massive liver ... #differential # ... diagnosis #algorithm
Causes of Ascites - Differential Diagnosis Algorithm
Portal Hypertension - Prehepatic:
 • Portal vein thrombosis
 • Splenic
Diagnosis Algorithm ... - Hepatic: • Cirrhosis ... • Infiltrative disease ... • Acute liver ... #Diagnosis #Algorithm
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
Hemochromatosis, Wilson's disease ... HELLP, Celiac disease ... #Diagnosis #hepatology ... #algorithm #Transaminitis ... #LFTs #hepatitis