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diagnosis differential causes aptt coagulation hepatology management prolonged pt amiodarone anemia bleeding bruising cvid disorders hemostasis hepatitis hypogammaglobulinemia immunodeficiency immunology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Differential Diagnosis Algorithm ... Chronic Disease Normal ... Renal Disease, Liver ... #Anemia #MCV #Classification ... #Causes #Hematology
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
deficiency in the common ... indirect inhibitory ... • Reduced liver ... amyloidosis #Abnormal ... #differential #hematology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... Early liver disease ... inhibitors to the common ... Reduced liver synthesis ... #differential #hematology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... Differential Diagnosis Algorithm ... disease US — Normal ... Bile Ducts • Common ... #Causes
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Differential Diagnosis Algorithm ... are present • Classic ... lymphadenopathy more diffuse ... Lymphoproliferative #Disorders #Classification ... pathophysiology #Hematology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Differential Diagnosis Algorithm ... Vascular Causes ... Half-life: 1 week • Direct ... function may be abnormal ... #hepatology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
PT/ABNORMAL PTT ... defects in the common ... discern these causes ... are liver function ... Differential #Diagnosis #Hematology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
disease • Liver ... CT: • Ground-glass ... levels are within normal ... DDX - Other causes ... hypogammaglobulinemia #immunology #hematology
Amiodarone Induced Lung Toxicity Summary Who? • 5% of patients • Dose ≥ 400 mg per day How? Possible
lung injury • Indirect ... pneumonia) is more common ... • Patchy or diffuse ... Eosinophilia • Normal ... in case of most common
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