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Renal Involvement in Systemic Lupus Erythematosus

Dr. Laurent ARNAUD @Lupusreference

#Renal #diseases #SLE #Systemic #Lupus #Erythematosus #venn #nephrology
Erythematosus ... SLE #Systemic #Lupus ... #Erythematosus ... nephrology #nephritis #classification ... #types #rheumatology
Lupus Nephritis Classification Algorithm

#Lupus #Nephritis #Classification #Algorithm #diagnosis #differential #types #rheumatology #nephrology #renal
Lupus Nephritis ... Classification Algorithm ... #Lupus #Nephritis ... #Classification ... #differential #types
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus
Clinical Domains:
 • Constitutional domain: Fever
 • Cutaneous domain: Non-scarring
EULAR/ACR Classification ... Erythematosus ... > 0.5 g/24 hr, Class ... , Class Ill or IV ... #Erythematosus
Lupus Nephritis Primer
Class I - Minimal Mesangial
Class II - Mesangial Proliferative
Class Ill - Focal Proliferative
Class IV
Lupus Nephritis ... Primer Class I - ... Proliferative Class ... DrFlashHeart #Lupus ... Nephritis #SLE #Classification
Hypersensitivity: Summary
Type I Hypersensitivity:
 • Immunological Mediator: lgE
 • Immunological Target: Allergen Molecules
 • Ex: Antibiotic
Hypersensitivity: Summary Type ... conjunctivitis Type ... • Ex: Systemic Lupus ... Erythematosus, ... #Classification
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
Hypersensitivity Types ... Their Mechanisms Type ... , and systemic lupus ... erythematosus ... #Classification
Management of Lupus Nephritis
Lupus nephritis (LN) in 10 to 40% of SLE
Hallmark = proteinuria 20.5 g/g
Management of Lupus ... Nephritis Lupus ... severity (ISN/RPS classification ... by 12 months Classification ... BaillouChloe #Lupus
Cutaneous Lupus Erythematosus
 • Acute Cutaneous Lupus (ACLE)
 • Neutrophilic Dermatoses 
 • Vascular Lesions
 •
Cutaneous Lupus ... Erythematosus ... #Erythematosus ... #diagnosis #types ... #rheumatology #classification
Type III Hypersensitivity: Pathogenesis and clinical findings
Definition: Small antigen-antibody complexes (produced from normal immune response to
Type III Hypersensitivity ... : • Systemic Lupus ... • Erythematosus ... sickness #TypeIII #Type3
Summary table of types of hypersensitivity reactions. 
Type 1
 - Mediators: lgE
 - Antigen Form: Soluble
Summary table of types ... Type 1 - Mediators ... glomerulonephritis, Systemic lupus ... erythematosus Type ... allergy #table #classification