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diagnosis differential shock criticalcare hemophagocytic hlh lymphohistiocytosis overview cellulitis hematology hemeonc histiocytosis idsa infections langerhans lch myelitis neurology rheumatology sepsis
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
→Activation of CD8 ... → Excessive activation ... accumulation of clinical ... , Hb), Hepatic dysfunction ... Lymphohistiocytosis #diagnosis #management
IDSA Algorithm for the Management of Purulent skin and soft tissue infections (SSTIs). Mild infection: for
IDSA Algorithm for ... the Management ... or those with clinical ... evidence of organ dysfunction ... including those caused
SEPSIS AND SEPTIC SHOCK DEFINITION AND PATHOPHYSIOLOGY • Sepsis: Life-threatening organ dysfunction due to a dysregulated host
cytokines, complement activation ... risk death), T-cell ... COMMON CAUSES + ... CLINICAL RECOGNITION ... CLINICAL FEATURES
Shock Overview A state of tissue hypoxia due to decreased or dysregulated oxygen delivery or extraction, resulting
rapidly progresses: cell ... death -> end-organ dysfunction ... death Common Clinical ... #diagnosis #management ... #differential #causes
Shock Overview A state of tissue hypoxia due to decreased or dysregulated oxygen delivery or extraction, resulting
rapidly progresses: cell ... death -> end-organ dysfunction ... death Common Clinical ... #diagnosis #management ... #differential #causes
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
bowel or bladder dysfunction ... • Excessive activation ... Transverse Myelitis - Clinical ... Pleocytosis > 100 cells ... Myelitis #diagnosis #management
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
recognition and management ... cytopenias and organ dysfunction ... hyperinflammatory syndrome caused ... Persistent fever, organ dysfunction ... Clinical Presentation
Langerhans Cell Histiocytosis (LCH) Granulomatous Lesions comprising langerin-positive histiocytes and an inflammatory infiltrate can arise in virtually
various tissues, leading ... populations) CLINICAL ... • Endocrine Dysfunction ... Birbeck granules (EM ... Histiocytosis #Diagnosis #Management
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