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diagnosis hematology apml complications diabetes diabeticfoot differential differentiation disorders histiocytosis igg4 langerhans lch lymphomas lymphoproliferative nonhodgkin oncology rheumatology syndrome
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Differential Diagnosis Algorithm ... Low Grade - Slow growing ... Lymphoproliferative #Disorders #Classification ... #pathophysiology ... #differential #algorithm
IGG-4 RELATED DISEASE WHAT? • A chronic, immune-mediated fibroinflammatory disease with tumefactive infiltration of IgG4+ plasma cells
- Organ dysfunction ... PATHOPHYSIOLOGY ... progressive organ dysfunction ... Cholangitis - mimics PSC ... complement • Classification
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
ATRA treatment Pathophysiology ... • Induce blast cell ... severe APLS, organ dysfuxtion ... fluid overload, PCC ... APML #diagnosis #management
Diabetic Foot: Pathogenesis and clinical findings • Polyol Pathway - Excess glucose enters Polyol pathway ->
accumulates in cells ... essential for cell ... increasing cytogenetic dysfunction ... • Increased PKC ... #DiabeticFoot #pathophysiology
Langerhans Cell Histiocytosis (LCH) Granulomatous Lesions comprising langerin-positive histiocytes and an inflammatory infiltrate can arise in virtually
various tissues, leading ... • Endocrine Dysfunction ... marrow: Organ dysfunction ... Birbeck granules (EM ... Histiocytosis #Diagnosis #Management
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