8 results
Pharmacokinetic Characteristics and Primary Routes of Clearance of Oral Anticoagulant Agents

Warfarin - 100% Hepatic, 0% Renal
Apixaban
Primary Routes of Clearance ... of Oral Anticoagulant ... Hepatic, 80% Renal Edoxaban ... Hepatic, 35% Renal #DOAC ... #oral #anticoagulation
DOAC: Cheat Sheet - Atrial Fibrillation, VTE Prophylaxis, VTE and Renal Dosing

Renal Dosing:
Apixaban (25% renal clearance):
DOAC: Cheat Sheet ... Apixaban (25% renal clearance ... if CrCl < 50) Edoxaban ... @Bloodman #DOAC ... Rivaroxaban #Dabigatran #Edoxaban
Oral anticoagulant dosing and bridging for VTE

- Dr. Joseph Shatzel @Clotmaster 

#VTE #DOAC #Bridging #Dosing #Oral
Oral anticoagulant ... dosing and bridging ... Clotmaster #VTE #DOAC ... #Bridging #Dosing ... #Rivaroxaban #Edoxaban
Patient risk stratification algorithm for the treatment of cancer-associated thrombosis.

Currently, edoxaban and rivaroxaban are the only
Currently, edoxaban ... direct-acting oral ... being stronger for edoxaban ... for appropriate dosing ... direct-acting oral
Perioperative Management of DOACs
Problem:
 ✖ Each year approximately 250,000 patients on chronic anticoagulation in North America
Management of DOACs ... direct acting oral ... recent creatinine clearance ... (calculated using ... ) • Apixaban, Edoxaban
Renal Replacement Therapy (RRT) - ICU One Pager Summary
Indications (AIEOU):
 • A: Acidosis (usually severe metabolic)
HD machine • CRRT ... a CRRT machine ... CRRT Modes: • SCUF ... Provides diffusive ... clearance by running
Renal Replacement Therapy (RRT) Modalities

RRT Modalities in the ICU:
 • IHD (Intermittent HD):  3-5 hr
provides almost no clearance ... Provides convective clearance ... Provides diffusive ... clearance by running ... High clearance achieved
Treatment algorithm for VTE in Malignancy

(A) Suggested treatment algorithm for symptomatic and incidental DVT or PE
**Edoxaban is initiated ... bleeding risk during ... DOAC, direct oral ... #DOAC #VTE #Malignancy