7 results
Pharmacokinetic Characteristics and Primary Routes of Clearance of Oral Anticoagulant Agents

Warfarin - 100% Hepatic, 0% Renal
Apixaban
Primary Routes of Clearance ... of Oral Anticoagulant ... Edoxaban - 50% ... #DOAC #NOAC #Metabolism ... #oral #anticoagulation
DOAC: Cheat Sheet - Atrial Fibrillation, VTE Prophylaxis, VTE and Renal Dosing

Renal Dosing:
Apixaban (25% renal clearance):
DOAC: Cheat Sheet ... Dosing Renal ... (25% renal clearance ... if CrCl < 50) Edoxaban ... @Bloodman #DOAC
Patient risk stratification algorithm for the treatment of cancer-associated thrombosis.

Currently, edoxaban and rivaroxaban are the only
Currently, edoxaban ... direct-acting oral ... for appropriate dosing ... direct-acting oral ... Management #Hematology #Oncology
Perioperative Management of DOACs
Problem:
 ✖ Each year approximately 250,000 patients on chronic anticoagulation in North America
Management of DOACs ... direct acting oral ... recent creatinine clearance ... (calculated using ... ) • Apixaban, Edoxaban
Treatment algorithm for VTE in Malignancy

(A) Suggested treatment algorithm for symptomatic and incidental DVT or PE
**Edoxaban is initiated ... bleeding risk during ... DOAC, direct oral ... #DOAC #VTE #Malignancy ... Management #Hematology #Oncology
Renal Replacement Therapy (RRT) - ICU One Pager Summary
Indications (AIEOU):
 • A: Acidosis (usually severe metabolic)
Renal Replacement ... CRRT (Continuous renal ... CRRT machine CRRT Modes ... Provides diffusive ... nephrology #CRRT #Modes
Renal Replacement Therapy (RRT) Modalities

RRT Modalities in the ICU:
 • IHD (Intermittent HD):  3-5 hr
Renal Replacement ... CRRT (Continuous renal ... machine CRRT Modes ... Provides diffusive ... nephrology #CRRT #Modes