11 results
Pharmacokinetic Characteristics and Primary Routes of Clearance of Oral Anticoagulant Agents

Warfarin - 100% Hepatic, 0% Renal
Apixaban
Primary Routes of Clearance ... of Oral Anticoagulant ... Hepatic, 25% Renal Dabigatran ... Hepatic, 80% Renal Edoxaban ... #oral #anticoagulation
Oral anticoagulant dosing and bridging for VTE

- Dr. Joseph Shatzel @Clotmaster 

#VTE #DOAC #Bridging #Dosing #Oral
Oral anticoagulant ... dosing and bridging ... Clotmaster #VTE #DOAC ... Anticoagulation #Dabigatran ... #Rivaroxaban #Edoxaban
DOAC: Cheat Sheet - Atrial Fibrillation, VTE Prophylaxis, VTE and Renal Dosing

Renal Dosing:
Apixaban (25% renal clearance):
Apixaban (25% renal clearance ... patients 5mg bid Dabigatran ... if CrCl < 50) Edoxaban ... #Rivaroxaban #Dabigatran ... #Edoxaban #NOAC
DOAC Cheat Sheet
 • Apixaban, Dabigatran, Edoxaban, Rivaroxaban
 • Renal Dosing
 • Common Drug interactions
 •
DOAC Cheat Sheet ... • Apixaban, Dabigatran ... , Edoxaban, Rivaroxaban ... • Renal Dosing ... DeLoughery @Bloodman #DOAC
Warfarin to DOAC and DOAC to Warfarin Transitions 

Here are a couple of charts to help
Warfarin to DOAC ... and DOAC to Warfarin ... for easier dosing ... : apixaban and dabigatran ... Edoxaban is <2.5
Patient risk stratification algorithm for the treatment of cancer-associated thrombosis.

Currently, edoxaban and rivaroxaban are the only
Currently, edoxaban ... direct-acting oral ... being stronger for edoxaban ... for appropriate dosing ... direct-acting oral
Perioperative Management of DOACs
Problem:
 ✖ Each year approximately 250,000 patients on chronic anticoagulation in North America
direct acting oral ... recent creatinine clearance ... (calculated using ... of Therapy • Dabigatran ... ) • Apixaban, Edoxaban
DOAC Reversal
Emergency surgery or urgent procedure
Stop anticoagulant treatment; volume resuscitation and transfusion as needed
Antidotes:
 • Apixaban,
DOAC Reversal Emergency ... : • Apixaban, Edoxaban ... modified factor Xa • Dabigatran ... not available #DOAC ... #Oral #anticoagulant
Effect of Direct Oral Anticoagulants on Hemostatic Tests
Horizontal bars correspond to the approximate range of detectability
Effect of Direct Oral ... concentrations of dabigatran ... , apixaban and edoxaban ... thrombin time #doac ... #noac #anticoagulation
Treatment algorithm for VTE in Malignancy

(A) Suggested treatment algorithm for symptomatic and incidental DVT or PE
**Edoxaban is initiated ... bleeding risk during ... DOAC, direct oral ... #DOAC #VTE #Malignancy