8 results
NOAC / DOAC Pharmacology and Prescribing Cheat Sheet
Novel (or Direct) Oral Anti-Coagulants
 • Rivaroxaban
 • Apixaban
Novel (or Direct) Oral ... Anti-Coagulants • Rivaroxaban ... • Apixaban • Dabigatran ... #Prescribing #hematology ... management #Direct #Oral
Oral anticoagulant dosing and bridging for VTE

- Dr. Joseph Shatzel @Clotmaster 

#VTE #DOAC #Bridging #Dosing #Oral
Oral anticoagulant ... Clotmaster #VTE #DOAC ... Anticoagulation #Dabigatran ... #Apixaban #Rivaroxaban ... #Pharmacology #Hematology
Pharmacokinetic Characteristics and Primary Routes of Clearance of Oral Anticoagulant Agents

Warfarin - 100% Hepatic, 0% Renal
Apixaban
Primary Routes of Clearance ... of Oral Anticoagulant ... Hepatic, 25% Renal Dabigatran ... Hepatic, 50% Renal Rivaroxaban ... Hepatic, 35% Renal #DOAC
DOAC: Cheat Sheet - Atrial Fibrillation, VTE Prophylaxis, VTE and Renal Dosing

Renal Dosing:
Apixaban (25% renal clearance):
Apixaban (25% renal clearance ... patients 5mg bid Dabigatran ... 60kg, CrCl 15-50 Rivaroxaban ... Anticoagulation #Hematology ... #Dabigatran #Edoxaban
DOAC Reversal
Emergency surgery or urgent procedure
Stop anticoagulant treatment; volume resuscitation and transfusion as needed
Antidotes:
 • Apixaban,
Apixaban, Edoxaban or Rivaroxaban ... modified factor Xa • Dabigatran ... not available #DOAC ... #Oral #anticoagulant ... #hematology #management
Patient risk stratification algorithm for the treatment of cancer-associated thrombosis.

Currently, edoxaban and rivaroxaban are the only
, edoxaban and rivaroxaban ... direct-acting oral ... for appropriate dosing ... direct-acting oral ... Anticoagulation #Management #Hematology
Perioperative Management of DOACs
Problem:
 ✖ Each year approximately 250,000 patients on chronic anticoagulation in North America
direct acting oral ... recent creatinine clearance ... (calculated using ... of Therapy • Dabigatran ... Apixaban, Edoxaban, Rivaroxaban
Effect of Direct Oral Anticoagulants on Hemostatic Tests
Horizontal bars correspond to the approximate range of detectability
Effect of Direct Oral ... concentrations of dabigatran ... , rixaroxaban, apixaban ... thrombin time #doac ... #hematology #laboratory