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diagnosis differential atlas blood morphology algorithm anemia bloodcell causes gap globulin hematuria hemolysis hemolytic key management microscopy nephrology nomenclature oncology
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
RBC) Morphology ... cells - Sickle ... cell anemia, Sickle-thalassemia ... coagulopathy (DIC) #RBC ... #differential #hematology
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Burr Cell RBC (Echinocyte ... Bite Cell RBC: G6PD ... disease, Artifact Sickle ... Cell RBC: Hemoglobin ... differential #diagnosis #hematology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
2) External (RBC ... Defects, Drugs, Liver ... Hemoglobin Defects: Sickle ... cell anemia, Thalassemias ... Differential #Diagnosis #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
cells - Consider ... sickle cell disease ... hypertension • Unusual RBC ... Diagnosis #Algorithm #workup ... #hematology #testing
Hematuria - Differential Diagnosis Framework Gross Hematuria: Red/Dark urine • 1ml blood/liter urine can induce color change
• 1ml blood/liter ... urine can induce color ... hematuria: - RBC ... Papillary necrosis (Sickle ... cell) • Renal
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
• Washed RBC ... • Single donor ( ... eruptions, diarrhea, liver ... potassium from lysed cells ... diagnosis #management #hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... Sarcoidosis) • Liver ... gastric tumors • Hematology ... cell anemia • ... differential #diagnosis #hematology
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
can present as a single ... common - GI tract, liver ... • CBC + diff • ... Oncology #Diagnosis #Workup ... #Hematology
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