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diagnosis rheumatology differential erythematosus sle systemic criteria cryoglobulinemia cryoglobulins eularacr gammopathy glomerulonephritis igg4 management mgrs monoclonal progressive rapidly renal rpgn
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
staining): • Low Complement ... Post-strep GN, Lupus ... Idiopathic • Normal Complement ... Glomerulonephritis #Vasculitis ... differential #diagnosis #algorithm
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
EULAR/ACR Classification ... Criteria for Systemic Lupus ... Erythematosus Clinical ... anticoagulant • Complement ... #EULARACR #Classification
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Vasculitis and Vasculitides ... inflammation Others: • Lupus ... such as systemic lupus ... against MPO • Complement ... #rheumatology #classification
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Syndrome: • Clinical ... • Low serum C4 complement ... • Vasculitis ... (e.g. systemic lupus ... diagnosis #types #classification
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... anti-Smith Ab, low complements ... Skin Disease Classification ... lymphoproliferative syndrome Clinical ... RNP antibodies, Complement
IGG-4 RELATED DISEASE WHAT? • A chronic, immune-mediated fibroinflammatory disease with tumefactive infiltration of IgG4+ plasma cells
specific) COMMON CLINICAL ... aortitis, mimics vasculitis ... Essential Criteria: Clinical ... - ↑ IgE, ↓ complement ... • Classification
Monoclonal Gammopathy of Renal Significance (MGRS) MGRS • MGRS refers to kidney disease caused by nephrotoxic monoclonal immunoglobulins
Clinical Clues: ... guide subtype classification ... tubulopathy) - Complement ... formation causing vasculitis
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