10 results
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
Rapidly Progressive Glomerulonephritis ... three primary pathophysiologic ... staining): • Low Complement ... Idiopathic • Normal Complement ... differential #diagnosis #algorithm
Maculopapular - Diagnostic Algorithm
Pathophysiology:
- Catch-all term with a wide range of potential pathophysiologic mechanisms and causative
Maculopapular - Diagnostic Algorithm ... Pathophysiology ... New-onset fever with rash ... #Dermatology #Rash ... Color #Targetoid #Algorithm
C5-C9 Deficiency - Pathogenesis and Clinical Findings
Note:
 • Risk of invasive meningococcal disease is 1000-10000x higher
is rare Normal complement ... response: The complement ... activation -> Complement ... Maculopapular rash ... #pathophysiology
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
antigen, leading to complement ... Complement activation ... Post-streptococcal glomerulonephritis ... Classification #Pathophysiology
Algorithm - Approach to the differential diagnosis of the patient presenting with overt glomerular proteinuria. CMV
Algorithm - Approach ... membrane; GN = glomerulonephritis ... maculopapular rash ... vesicular rash, ... #Algorithm #differential
Erythroderma - Diagnostic Algorithm. Pathophysiology: 1) Extensive cutaneous capillary dilation, results in widespread exfoliation of the
Erythroderma - Diagnostic Algorithm ... Pathophysiology: ... #Dermatology #Rash ... Erythroderma #Nikolsky #Algorithm
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
- Necrotizing glomerulonephritis ... , pauci-immune glomerulonephritis ... arthritis. (± glomerulonephritis ... mucositis - Rash ... against MPO • Complement
Petechiae/Purpura - Diagnostic Algorithm. Pathophysiology: 1) Represent the passage of erythrocytes from the intravascular to extravascular
Purpura - Diagnostic Algorithm ... Pathophysiology: ... #Dermatology #Rash ... Purpura #Palpable #Algorithm
Secondary Causes of Hypertension - Differential Diagnosis Algorithm
Hypertension - BP > 140/90 (>130/80 for DM)
Hypertensive urgency
Differential Diagnosis Algorithm ... Parenchymal Diseases • Glomerulonephritis ... • Bilateral RAS ... • Unilateral RAS ... Differential #Diagnosis #Algorithm
Amebiasis - Balamuthia mandrillaris Life Cycle
1) Cysts
2) Trophozoite
3) Mitosis
4) Amebae (cysts and trophozoites) can enter humans
who are immune competent ... #mandrillaris #LifeCycle ... #diagnosis #pathophysiology