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management aspergillus betadglucan biomarkers causes differential galactomannan acute antibiotics bacteremia bloodstream catheter chronic crbsi febrile fungi fungus fuo infant infection
Important Fungal Stains Mycology Lab: • Calcofluor white - Fluorochrome that binds glucans and chitin in fungal
polysaccharide component ... #microbiology #microscopy ... #staining #diagnosis ... #fungi #fungus ... #comparison #table
Fungal Biomarkers: Comparing Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi •
Fungal Biomarkers ... Polysaccharide cell wall component ... of many fungi ... Galactomannan #diagnosis ... #comparison #microbiology
Rigors And Bacteremia - Overview • Rigors are a response to the release of cytokines and prostaglandins
hypothalamus → fever ... Lipopolysaccharide components ... Double-stranded RNA • Fungi ... Mannan and glucan components ... InfectiousDiseases #Diagnosis
Causes of Fever of Unknown Origin (FUO) - Differential Diagnosis Algorithm Neoplasm: • NHL • Hodgkin's lymphoma • Leukemia • Solid
- Differential Diagnosis ... Algorithm Neoplasm ... Recurrent PE Bacterial ... Infection: • Fungal ... #Algorithm #causes
Causes of Acute Onset Fever - Differential Diagnosis Algorithm Viral: • Rhinovirus • Influenza Virus • Parainfluenza
- Differential Diagnosis ... Algorithm Viral ... Infectious - Other: • Fungal ... #Differential #Diagnosis ... #Algorithm #causes
“Step by Step” – the new kid on the block – aims to risk stratify this
risk of serious bacterial ... for each of the components ... of the algorithm ... an infant with fever ... CRP < 20 mg/L #Diagnosis
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi • Pathogens:
Fungal Biomarkers ... Polysaccharide cell wall component ... post-2010 almost never ... Galactomannan #diagnosis ... #comparison
Suspected catheter-related bloodstream infection - Management Algorithm • Temperature 37.8 C • Rigors
• Persistent fever ... and/or bacteremia ... and/or bacteremia ... pathogens (S. aureus, fungal ... #CRBSI #diagnosis
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
Nonspecific symptoms: Fever ... connective tissue components ... ○ Syphilis ○ Fungal ... ○ Bacterial ... /EGPA • RA Diagnosis
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