25 results
Fever - Pyrogen Pathophysiology

EXOGENOUS PYROGEN
 • Bacteria: Lipopolysaccharide components, peptidoglycans and muramyl peptide derivatives, Toxins
 •
Pathophysiology ... Lipopolysaccharide components ... stranded RNA • Fungi ... thermoregulatory set point ... #Fever #Pathophysiology
Approach to Joint Pain - Diagnostic Framework

1) Chronicity
2) Inflammatory vs Non-Inflammatory
3) Number of Joints Involved

1) Chronicity:
Pain - Diagnostic ... acute rheumatic fever ... • Chronic - Think ... #Joint #Pain #MSK ... #differential #diagnosis
Chronic Shoulder Pain - Differential Diagnosis Algorithm
4 tests for the AC joint:
1. Direct palpation
2. Cross-arm shoulder
Chronic Shoulder ... - Differential Diagnosis ... Algorithm 4 tests ... for the AC joint ... #Algorithm #MSK
Inflammatory Joint Pain - Differential Diagnosis Algorithm 
Monoarticular
 • Gout (Podagra, Tophi)
 • Pseudogout
 • Early
- Differential Diagnosis ... Algorithm Monoarticular ... • Rheumatic Fever ... • Rheumatic Fever ... Inflammatory #JointPain #MSK
Approach to Joint Pain - Arthritis Differential Diagnosis Framework

Inflammatory Versus Noninflammatory Pain
 • Is it inflammatory
Arthritis Differential Diagnosis ... Mycobacterial • Fungal ... • Rheumatic fever ... tuberculosis) • Fungi ... #MSK #rheumatology
Infectious Joint Pain - Differential Diagnosis Algorithm 
Polyarticular Join Pain
 • Viral Myalgia
 • Viral Arthritis
Infectious Joint ... - Differential Diagnosis ... Join Pain • Viral ... Onset • Fungal ... Infectious #JointPain #MSK
Rigors And Bacteremia - Overview

• Rigors are a response to the release of cytokines and prostaglandins
hypothalamus → fever ... PATHOPHYSIOLOGY: ... Double-stranded RNA • Fungi ... Mannan and glucan components ... InfectiousDiseases #Diagnosis
Causes of Fever of Unknown Origin (FUO) - Differential Diagnosis Algorithm
Neoplasm:
• NHL
• Hodgkin's lymphoma
• Leukemia
• Solid
- Differential Diagnosis ... Algorithm Neoplasm ... Infection: • Fungal ... UnknownOrigin #FUO #Chronic ... #Algorithm #causes
Chronic Joint Pain - Differential Diagnosis Algorithm 
Intra-Articular
 - Bone
     • Stress
Chronic Joint Pain ... - Differential Diagnosis ... Algorithm Intra-Articular ... Ossificans #Chronic ... Intraarticular #MSK
Approach to Joint Pain

History:
Is the pain from:
	• Joint
	• Adjacent bursa
	• Tendon
	• Ligament
	• Bone
	• Muscle
	• Referred from
Approach to Joint ... : • Acute or chronic ... to bacterial, fungal ... #Pain #MSK #rheumatology ... #differential #diagnosis