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diagnosis management rheumatology latenttb tb tuberculosis aspergillus bacteremia betadglucan biomarkers calcium deposition disease fever galactomannan gout hemeonc hemophagocytic hlh infectiousdiseases
Fever - Pyrogen Pathophysiology EXOGENOUS PYROGEN • Bacteria: Lipopolysaccharide components, peptidoglycans and muramyl peptide derivatives, Toxins •
Fever - Pyrogen Pathophysiology ... Lipopolysaccharide components ... stranded RNA • Fungi ... Mannan and glucan components ... vasculature via: • Active
CPPD vs Gout == CPPD == Think About CPPD When: • Self-limited synovitis after surgery/trauma (> 65
CPPD vs Gout ... disease states Pathophysiology ... deposit and can activate ... #Gout #Comparison ... #rheumatology #
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi • Pathogens:
Fungal Biomarkers ... Polysaccharide cell wall component ... infection (IFI) in hematologic ... admin of mold-active ... Galactomannan #diagnosis #comparison
Rigors And Bacteremia - Overview • Rigors are a response to the release of cytokines and prostaglandins
PATHOPHYSIOLOGY: ... Lipopolysaccharide components ... Double-stranded RNA • Fungi ... Mannan and glucan components ... vasculature via: • Active
Tuberculosis Overview 10 million new M. tuberculosis infections/year Facultative intracellular rod-shaped bacteria Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
tuberculosis (LTBI) Pathophysiology ... infection (NTM) • Fungal ... assay (IGRA) • PPD ... Tuberculosis Treatment ... Initiating Treatment
TRALI vs TACO - Transfusion Reactions TRALI: • Epidemiology: 0.1% of transfused patientsl • Risk factors: Critical
blood donor • Pathophysiology ... : 33% • Treatment ... : No • Treatment ... Transfusion #Reactions #hematology ... #diagnosis #comparison
Tuberculosis Overview 10 million new M. tuberculosis infections/year Facultative intracellular rod-shaped bacteria Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
tuberculosis (LTBI) Pathophysiology ... infection (NTM) • Fungal ... assay (IGRA) • PPD ... Tuberculosis Treatment ... Initiating Treatment
Pseudogout Summary - Calcium Pyrophosphate Deposition Disease (CPPD) Pathophysiology: Pyrophosphate produced by chondrocytes likely precipitates with calcium to
) Pathophysiology ... calcium to form CPP ... deposit and can activate ... Acute Pseudogout: Treatment ... Deposition #Disease #Rheumatology
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
connective tissue components ... ○ Syphilis ○ Fungal ... affected tissue Treatment ... Polychondritis #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
search for and treatment ... Pathophysiology ... absent NK-cell activity ... Treatment Approach ... Diagnosis #Management #Hematology
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