16 results
Gitelman Syndrome Pathophysiology
Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Gitelman Syndrome ... Pathophysiology ... Gitelman Syndrome ... Hypokalemia Metabolic alkalosis ... #Syndrome #Pathophysiology
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting, NGT
Primary Metabolic Alkalosis ... Differential Diagnosis Algorithm ... , Gitelman Syndrome ... Primary #Metabolic #Alkalosis ... #nephrology
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted - 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting,
Primary Metabolic Alkalosis ... Differential Diagnosis Algorithm ... , Gitelman Syndrome ... Differential #Diagnosis #Algorithm ... #Nephrology #Causes
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
Gitelman Syndrome ... Hypokalemia (renal potassium ... Supplement: • Potassium ... #nephrology #management ... #pathophysiology
Hypokalemia - Differential Diagnosis Algorithm
Extra-renal Losses:
 • Normal Acid-Base: Low intake
 • Metabolic acidosis: Gl tract
Differential Diagnosis Algorithm ... , Gitelman syndrom ... Differential #Diagnosis #Algorithm ... #causes #potassium ... #low #nephrology
Hypokalemia Evaluation Algorithm

Before evaluating hypokalemia, life threatening complications such as arrhythmias and paralysis should be looked
Hypokalemia Evaluation Algorithm ... treated with IV potassium ... - Metabolic Alkalosis ... , Gitelman syndrome ... #nephrology #low
Hypochloremia - Differential Diagnosis Algorithm

Cause - Decreased Intake:
 • Low salt in diet
 • Exclusive D5W
Differential Diagnosis Algorithm ... - Metabolic alkalosis ... - Bartter - Gitelman ... Cl⁻ with other components ... #Pathophysiology
Metabolic Alkalosis - Urinary Chloride Algorithm
Cl- responsive metabolic alkalosis
 • Kidney loss of Cl-
Urinary Chloride Algorithm ... diuretic use, Bartter syndrome ... , Gitelman syndrome ... of sodium and potassium ... Chloride #urine #Algorithm
Hypokalemia - Differential Diagnosis Algorithm

Transcellular Shift:
 • Alkalosis
 • ↑ beta-2 adrenergic simulation 
 • Erythropoiesis
Differential Diagnosis Algorithm ... Transcellular Shift: • Alkalosis ... • Refeeding syndrome ... #nephrology #low ... #potassium
Causes of Metabolic Alkalosis: Differential Diagnosis
ECF volume contracted: urine chloride concentration <20 meq/L
 • Gastric alkalosis:
Causes of Metabolic Alkalosis ... /L • Gastric alkalosis ... furosemide-like lesion) • Gitelman ... other • Severe potassium ... Diagnosis #Causes #nephrology