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diagnosis hepatology differential management transaminitis chemistry dili drug gastroenterology grading hepatic hepatitis hepatocellular idiosyncratic induced interpretation rvalue treatment
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Injury (DILI) ... dose dependent injury ... Chronic - ongoing ↑ LFTs ... gastroenterology #algorithm ... gastroenterology #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
Injury - Differential ... Injury → liver ... #Diagnosis #hepatology ... #algorithm #Transaminitis ... #LFTs #hepatitis
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... injury < 26 weeks ... INR > 1.5 • Encephalopathy ... #differential #Hepatology ... transaminitis #LFTs
Hepatic Encephalopathy - Diagnosis and Management Summary Definition: • Alteration in brain function manifested by neuropsychiatric symptoms
Hepatic Encephalopathy ... • Caused by liver ... but responsive), Confusion ... LizzieAbyMD #Hepatic #Encephalopathy ... #Grading #Classification
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