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diagnosis management causes dermatology differential rheumatology generalized pruritus activation cerebritis erythematosus hemeonc hemophagocytic hlh lupus lymphohistiocytosis macrophage mas naildisorders neurology
Nail Disorders secondary to Systemic Diseases Nail Fold Abnormality • SLE • Scleroderma • Dermatomyositis Koilonychia - Spoon-shaped
Iron deficiency anemia ... discoloration) • Liver ... • Nephrotic syndrome ... #Secondary #dermatology ... Differential #Diagnosis #Algorithm
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
Differential Diagnosis Algorithm ... • Cholestatic liver ... renal failure/uremia ... Myelodisplastic syndrome ... Pruritus #primary #secondary
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
CNS Manifestations ... of Systemic Lupus ... Demyelinating Syndrome ... APS), Secondary ... #neurology #rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Classified among the secondary ... (CNS) dysfunction ... with leukopenia, anemia ... thrombocytopenia • Liver ... Diagnosis #Management #Hematology
Pruritus - No Primary Skin Lesion - Differential Diagnosis Algorithm Blood Glucose: • Diabetes Mellitus Liver Function Tests/Enzymes:
• Cholestatic liver ... renal failure/uremia ... Myelodisplastic syndrome ... #Pruritus #secondary ... #systemic #generalized
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
other diseases • Secondary ... Parotid swelling CNS ... • 8%-27% for CNS ... vasculitis: 10%-16% Liver ... Nephrogenic DI Hematologic
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
infection risk secondary ... disease • Liver ... autoimmune hemolytic anemia ... ) • Systemic granulomatous ... hypogammaglobulinemia #immunology #hematology
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
of the immune system ... STX11, STXBP2 • Secondary ... - Cytopenias (anemia ... - Elevated liver ... Diagnosis #Management #Hematology
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