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hematology oncology differential algorithm classification management anemia clinical diffuse disorders extravascular gangrenosum hemolysis hemolytic intravascular leukemia lymphadenopathy lymphoma lymphoproliferative mds
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
from mature B cells ... cells and Reed-Sternberg ... cells. ... • The tumor cells ... #lymphoma #diagnosis
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
- Differential Diagnosis ... Algorithm Hodgkin ... Reed-Sternberg (RS) Cells ... Lymphocyte - 5% RS cells ... (LP) tumour B cells
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Causes of Diffuse ... - Differential Diagnosis ... Cells on Biopsy ... Lymphadenopathy #LAD ... #Hematology #Oncology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
lymphadenopathy • Blast cells ... Rapidly rising blast cells ... : Granulocytic cells ... organs When Cancer Cells ... #Diagnosis
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... Extravascular Causes ... , lymphoma, idiopathic ... and lead poisoning ... #hematology #anemia
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
aggregate foci (>50 cells ... , B cells, and plasma ... cells around salivary ... lymphoma • B cell ... B cell lymphoma
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
group of disorders caused ... compounds, alcohol, lead ... treatments • Copper ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
arises from plasma cells ... from the plasma cells ... monoclonal plasma cells ... clonal plasma cells ... Lymphoma (NHL)
Pyoderma Gangrenosum (PG) 50 M Crohn’s dz had a small pustule on the ankle 4 mo ago
50 M Crohn’s dz had ... Diagnosis? ... neutrophils & T-cells ... #PG #clinical #photo ... #dermatology #ulcer
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