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oncology differential algorithm classification lymphoma management anemia blastomycosis chronic clinical comparison disorders hemolytic heon hypereosinophilia leukemia lymphocytic lymphomas lymphoproliferative mds
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
typically of B-cell ... type (B cell, T ... cells, natural ... killer (NK) cells ... #differential #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
cells can infiltrate ... smear: Smudge cells ... or basket cells ... #workup #oncology ... #hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
from mature B cells ... cells and Reed-Sternberg ... cells. ... Workup: • Full ... classification #hematology
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Reed-Sternberg (RS) Cells ... (LP) tumour B cells ... common - T Cell ... ~10% - B-Cell ... pathophysiology #Hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... treatments • Copper ... Workup: • Complete ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology
Ulcerative Blastomycosis Skin Lesion 57 asymptomatic M from Indiana nonpruritic, painless, progressive skin lesion lower back x
an old house & works ... Diagnosis? ... differential: basal cell ... ca, squamous cell ... Blastomycosis #SkinRash #dermatology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
- Differential Diagnosis ... Algorithm • Sickle cells ... Consider sickle cell ... #Algorithm #workup ... #hematology #testing
When to look for clonal/neoplastic hypereosinophilia (HEo)? - Exclusion of frequent causes (Drug-induced HEo, helminthiasis, cancer,
Cytopenia, Other cell ... BM biopsy (Mast cells ... hypereosinophilia #HEON #Diagnosis ... #Signs #Hematology ... #Workup
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
aggregate foci (>50 cells ... , B cells, and plasma ... cells around salivary ... lymphoma • B cell ... lymphoma • Large B cell
Polycythemia - Differential Diagnosis Algorithm Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
Too many cells in ... Better call hematology ... a good idea to call ... #Algorithm #workup ... #hematology
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