46 results
Suggested algorithm for bone marrow biopsy and skeletal imaging in patients with monoclonal gammopathy of undetermined
significance (MGUS ... /dL) IgM MGUS, low-risk ... MGUS (IgG type, ... - protein <1.5 gm ... 8) light-chain MGUS
Monoclonal Gammopathy Testing
Strengths, Weaknesses and Accuracy Compared
 - SPEP 
 - IFE 
 - FLC
Protein #Diagnosis #MGRS ... #MGUS #SPEP #IFE ... Laboratory #Comparison #Table
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework

Hematologic disorder characterized by the presence of either
Significance (MGUS ... Prevalence M > F MGUS ... IgM MGUS: • Serum ... MGUS: • Serum ... protein level (non-IgM
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis

Neurologic-Centered:
 (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
Significance (MGUS ... Renal-centered (ie "MGRS ... • Organized Ig ... immunotactoid GN, Type I cryo ... #Significance #MGUS
Rouleaux formation is common in IgM gammopathy and may be particularly striking

Genevieve Crane, MD, PhD@evemariecrane

#Rouleaux #formation
formation is common in IgM ... Rouleaux #formation #IgM ... #gammopathy #MGUS
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
• MM • WM • MGUS ... • MGCSMGRS ... Dermato-neuro syndrome) MGRS ... anemia due to cold IgG ... anticoagulant • IgM
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
or IgM - Cell-bound ... antigen - IgG ... or IgM antibody ... IgM - Soluble antigen ... Diagnosis #Reactions #Table
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Idiopathic monoclonal IgM ... Immunoglobulin M (IgM ... Infections: Polyclonal IgM ... Diagnosis Monoclonal IgM ... significance (MGUS
Summary table of types of hypersensitivity reactions. 
Type 1
 - Mediators: lgE
 - Antigen Form: Soluble
Summary table of ... - Mediators: IgG ... / IgM - Antigen ... /lgM antibodies ... types #allergy #table
Commonly Used Diagnostic Tests for Celiac Disease

Tissue transglutaminase (tTG) IgA antibodies
 - Most reliable noninvasive test
negative with IgA ... patients with IgA ... antibody test IgG ... patients with IgA ... Diagnosis #Workup #Table