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diagnosis differential causes infectiousdiseases infections concurrent management cardiology endocarditis fungal aspergillus betadglucan biomarkers cns culture galactomannan lesions mycoses negative neurology
Causes of Culture Negative Abscess - Differential Diagnosis Framework Consider prior antibiotics as a cause of a
Culture Negative Abscess ... negative culture Brain ... : Aspergillus, Cryptococcus ... nocardia - Fungal: Cryptococcus ... Coccidiomycosis, Cryptococcus
CNS Ring-Enhancing Lesions - Immunocompromised vs Immunocompetent Multiple Ring-Enhancing Lesions: • Toxoplasmosis (CD4 < 100) • Other
lesions • 80% with lung ... histoplasmosis, cryptococcus ... Syphilis • Pyogenic Abscess ... RingEnhancing #Lesions #Brain
Lung Abscess - Diagnosis and Management Summary Lung Abscess Etiology: • Necrosis of lung parenchyma by a
Lung Abscess - Diagnosis ... Abscess Etiology ... Lung abscess ... Lung Abscess - Clinical ... Dermatitidis - Cryptococcus
Differential Diagnosis for Concurrent Brain and Lung Infections • Bacteria: Strep anginosus, Staph aureus, Klebsiella pneumoniae
for Concurrent Brain ... and Lung Infections ... Mucormycosis, Cryptococcus ... @ID_fellows #Brain ... #Lung #Infections
Concurrent Brain and Lung Lesions • Bacteria: Nocardia spp, Strep anginosus, Staph aureus, Klebsiella pneumoniae (hypervirulent),
Concurrent Brain ... and Lung Lesions ... Mucormycosis, Cryptococcus ... febrilepodcast #Brain ... #Lung #Infections
Concurrent Brain and Lung Lesions • Bacteria: Nocardia spp, Strep anginosus, Staph aureus, Klebsiella pneumoniae (hypervirulent),
Concurrent Brain ... and Lung Lesions ... Mucormycosis, Cryptococcus ... febrilepodcast #Brain ... #Lung #Infections
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi • Pathogens:
- Negative: Cryptococcus ... Paecilomyces, Cryptococcus ... Clav (may be + as long ... Galactomannan #diagnosis #comparison
Endocarditis Summary Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV substance use • IV catheter • Recent
verrucous) • Lung ... Aspergillus • Cryptococcus ... suggests perivalvular abscess ... annular or aortic abscess ... Complications: Abscess
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
Fluconazole CRYPTOCOCCUS ... level, presence of cryptococcal ... CSF and serum Cryptococcal ... • Sinusitis • Brain ... abscess • Disseminated
Endocarditis - Overview and Differential Diagnosis Framework Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV
, verrucous) - Lung ... Aspergillus • Cryptococcus ... suggests perivalvular abscess ... annular or aortic abscess ... Complications: Abscess
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