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diagnosis differential causes infections infectiousdiseases fungal lung comparison abscess betadglucan biomarkers candida candidemia cns culture fungemia fungi fungus galactomannan lesions
Important Fungal Stains Mycology Lab: • Calcofluor white - Fluorochrome that binds glucans and chitin in fungal
exceptions are Aspergillus ... polysaccharide capsule of Cryptococcus ... detection for cryptococcal ... mucopolysaccharide capsule of Cryptococcus ... #microbiology #microscopy
Concurrent Brain and Lung Lesions • Bacteria: Nocardia spp, Strep anginosus, Staph aureus, Klebsiella pneumoniae (hypervirulent),
Concurrent Brain ... ) • Fungi: Aspergillus ... Mucormycosis, Cryptococcus ... febrilepodcast #Brain ... Lung #Infections #Concurrent
Concurrent Brain and Lung Lesions • Bacteria: Nocardia spp, Strep anginosus, Staph aureus, Klebsiella pneumoniae (hypervirulent),
Concurrent Brain ... ) • Fungi: Aspergillus ... Mucormycosis, Cryptococcus ... febrilepodcast #Brain ... Lung #Infections #Concurrent
Causes of Culture Negative Abscess - Differential Diagnosis Framework Consider prior antibiotics as a cause of a
negative culture Brain ... Mycobacteria - Fungal: Aspergillus ... , Cryptococcus, ... nocardia - Fungal: Cryptococcus ... Coccidiomycosis, Cryptococcus
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi • Pathogens:
Beta-D-Glucan and Aspergillus ... Pathogens: Candida, Aspergillus ... - Negative: Cryptococcus ... Paecilomyces, Cryptococcus ... decreased with: concurrent
Differential Diagnosis for Concurrent Brain and Lung Infections • Bacteria: Strep anginosus, Staph aureus, Klebsiella pneumoniae
Diagnosis for Concurrent ... Brain and Lung ... Mucormycosis, Cryptococcus ... @ID_fellows #Brain ... Lung #Infections #Concurrent
CNS Ring-Enhancing Lesions - Immunocompromised vs Immunocompetent Multiple Ring-Enhancing Lesions: • Toxoplasmosis (CD4 < 100) • Other
histoplasmosis, cryptococcus ... , and aspergillus ... RingEnhancing #Lesions #Brain
Invasive Fungal Infection (IFI) Invasive fungal infections are severe infections in which fungal pathogens invade normally sterile
bloodstream infections) Aspergillus ... pulmonary infections) Cryptococcus ... Diagnosis Culture and microscopy ... galactomannan, cryptococcal
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
Fluconazole CRYPTOCOCCUS ... level, presence of cryptococcal ... CSF and serum Cryptococcal ... ASPERGILLOSIS • Aspergillus ... • Sinusitis • Brain
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