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diagnosis differential causes infections infectiousdiseases concurrent fungal abscess comparison management pulmonary aspergillus betadglucan biomarkers cd4 cns culture evaluation fungus galactomannan
Important Fungal Stains Mycology Lab: • Calcofluor white - Fluorochrome that binds glucans and chitin in fungal
cell response to fungi ... polysaccharide capsule of Cryptococcus ... detection for cryptococcal ... mucopolysaccharide capsule of Cryptococcus ... fungus #comparison #table
Pulmonary Infections in HIV-AIDS Bacterial: • No organism identified, Strep pneumoniae, H. influenzae, S.aureus, Streptococcus Grp
> 200: Endemic fungi ... Aspergillus spp, Endemic fungi ... (Histoplasma, Cryptococcus ... failure, COPD, Lung ... ABG, BDG, Serum Cryptococcal
Differential Diagnosis for Concurrent Brain and Lung Infections • Bacteria: Strep anginosus, Staph aureus, Klebsiella pneumoniae
for Concurrent Brain ... and Lung Infections ... Toxoplasmosis • Fungi ... Mucormycosis, Cryptococcus ... #Lung #Infections
Causes of Culture Negative Abscess - Differential Diagnosis Framework Consider prior antibiotics as a cause of a
negative culture Brain ... : Aspergillus, Cryptococcus ... Scedosporium, endemic fungi ... nocardia - Fungal: Cryptococcus ... Coccidiomycosis, Cryptococcus
Concurrent Brain and Lung Lesions • Bacteria: Nocardia spp, Strep anginosus, Staph aureus, Klebsiella pneumoniae (hypervirulent),
Concurrent Brain ... and Lung Lesions ... ) • Fungi: Aspergillus ... Mucormycosis, Cryptococcus ... #Lung #Infections
Concurrent Brain and Lung Lesions • Bacteria: Nocardia spp, Strep anginosus, Staph aureus, Klebsiella pneumoniae (hypervirulent),
Concurrent Brain ... and Lung Lesions ... ) • Fungi: Aspergillus ... Mucormycosis, Cryptococcus ... #Lung #Infections
CNS Ring-Enhancing Lesions - Immunocompromised vs Immunocompetent Multiple Ring-Enhancing Lesions: • Toxoplasmosis (CD4 < 100) • Other
lesions • 80% with lung ... histoplasmosis, cryptococcus ... RingEnhancing #Lesions #Brain
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi • Pathogens:
component of many fungi ... - Negative: Cryptococcus ... Paecilomyces, Cryptococcus ... Clav (may be + as long ... closely related fungi
Lung Abscess - Diagnosis and Management Summary Lung Abscess Etiology: • Necrosis of lung parenchyma by a
Lung Abscess - Diagnosis ... • Necrosis of lung ... antibiotics once stable ... shows a small, stable ... Dermatitidis - Cryptococcus
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
Fluconazole CRYPTOCOCCUS ... level, presence of cryptococcal ... CSF and serum Cryptococcal ... • Sinusitis • Brain ... change in the lungs
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