16 results
Eosinophil Disorders Testing Algorithm
INDICATIONS FOR TESTING:
 • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
Eosinophil Disorders ... evaluation or workup ... 1,500 cells/µL Workup ... Disorders #Algorithm #Differential ... #diagnosis #hematology
Causes of Eosinophilia - Differential Diagnosis
Bugs:
 - Fungus (aspergillosis)
 - Viral (HIV)
 - Ectoparasites (scabies, myiasis)
Causes of Eosinophilia ... - Differential ... - DRESS - AIN ... #Differential # ... Diagnosis #Causes #hematology
Approach to Joint Pain - Diagnostic Framework

1) Chronicity
2) Inflammatory vs Non-Inflammatory
3) Number of Joints Involved

1) Chronicity:
Pain - Diagnostic ... Inflammatory, crystalline ... #Joint #Pain #MSK ... approach #workup ... #differential #
Hypereosinophilia Syndrome (HES) - Diagnosis and Management
Definition: An absolute eosinophil count (AEC) greater than 1500 and
Diagnosis and Management ... with blood eosinophilia ... #diagnosis #hematology ... #differential # ... management #eosinophils
Skin Conditions Associated with Joint Pain

Rash
	• Human parvovirus B19 infection

Malar rash
	• SLE
	• Human parvovirus B19 infection
	•
Associated with Joint ... Pain Rash ... Amyloidosis • Eosinophilic ... #joint #pain #skin ... #rashes #differential
Causes of Bone/Joint Pain in Sickle Cell Disease
Vaso-occlusive pain:
 • Mechanism: ischemic pain
 • Can present
Causes of Bone/Joint ... • Differentiate ... BrighamChiefs #Bone #Joint ... #Disease #differential ... diagnosis #causes #hematology
Approach to Joint Pain

History:
Is the pain from:
	• Joint
	• Adjacent bursa
	• Tendon
	• Ligament
	• Bone
	• Muscle
	• Referred from
Pain History ... : Is the pain from ... #Pain #MSK #rheumatology ... #approach #workup ... #differential #
Extra-articular and Other Conditions Associated with Joint Pain

Eyes
  • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
Associated with Joint ... Pain Eyes ... Amyloidosis • Eosinophilic ... #pain #differential ... #diagnosis #rheumatology
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
Cryoglobulinemic GN • Crystalline ... Scleromyxedema (CNS+GI+CVS+joints ... Episodic angioedema+eosinophilia ... Paraproteinemias #Hematology ... #Monoclonal #Differential
Causes of Knee Effusions - Differential Diagnosis Framework

Knee Effusion Red Flags:
1. Fever/Chills/Joint pain/Night sweats/Weight loss
	- DDX:
		-
Knee Effusions - Differential ... Fever/Chills/Joint ... pain/Night sweats ... Effusions: - Hematologic ... Osteosarcoma - Eosinophils