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management oncology causes classification rheumatology acidosis chronic cll coagulation dic differential disease disseminated elevation erythematosus hemeonc hemophagocytic hlh hodgkins igg4
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Diagnosis: • ... • Neutropenia, anemia ... microglobulin Treatment ... #workup #oncology ... #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... factor (GCSF) treatments ... Workup: • Complete ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... Lysis of tumor cells ... intracellular contents ... Syndrome #TLS #diagnosis ... #management #hematology
IgG4-Related Disease Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor 4 phenotypes: •
relapse No specific laboratory ... increased IgG4+ cells ... " Treatment: ... management #phenotypes #workup ... #treatment #rheumatology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Weight loss • Anemia ... Immune hemolytic anemia ... Hodgkin Lymphoma Workup ... Hodgkin Lymphoma Treatment ... classification #hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
protein C and S Pathophysiology ... venipuncture sites Laboratory ... Schistocytes, helmet cells ... #Coagulation #diagnosis ... #management #hematology
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
e.g., uptake by cells ... - assess other laboratory ... before beginning treatment ... Arterial Oxygen Content ... 30mmHg) - Severe anemia
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
and fever) and laboratory ... Differential Diagnosis ... syndrome in the context ... lymphopenia, low PLT • Anemia ... : • Chronic B-cell
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
search for and treatment ... - Cytopenias (anemia ... Pathophysiology ... Treatment Approach ... #Management #Hematology
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
Diagnosis? ... • No CRAB - no anemia ... EMD myeloma Diagnostic ... Bone marrow Treatment ... #Workup #Hematology
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