10000 results
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
pro-inflammatory cytokines ... hemophagocytosis and cytokine ... fever syndromes Clinical ... Fever is the main clinical ... Activation #Syndrome #Diagnosis
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
: Overwhelming clinical ... activation and cytokine ... Presentation / Diagnosis ... Diagnosis via genetic ... Infection should be diagnosed
KSHV Inflammatory Cytokine Syndrome (KICS)
Working Case Definition for KICS: Requires at least 2 clinical manifestations (from
KSHV Inflammatory Cytokine ... Requires at least 2 clinical ... 3, and 4. 1) Clinical ... #Inflammatory #Cytokine ... Syndrome #Kaposi #diagnosis
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
pro-inflammatory cytokines ... Auto-amplification loop Diagnosis ... accumulation of clinical ... Assessment • Clinical ... Lymphohistiocytosis #diagnosis
IgA Vasculitis – Henoch Scholein Purpura: Pathogenesis and Clinical Findings

 - Infectious Agents - 50% have
Pathogenesis and Clinical ... Interleukin 8 (IL8) - cytokine ... Pathophysiology #Diagnosis
Renal Cell Carcinoma (RCC) - Diagnosis and Management Summary
Clinical features - Classic triad (flank pain, hematuria,
Carcinoma (RCC) - Diagnosis ... Management Summary Clinical ... ), Recombinant cytokines ... Carcinoma #RCC #Diagnosis
Hypothermia in Sepsis - Pathophysiology
 • 20% of septic pts → HYPOTHERMIA
 • Increased mortality 62%
proinflammatory cytokines ... anti-inflammatory cytokine
Sarcoidosis - Diagnosis and Management Summary
Epidemiology
1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
Sarcoidosis - Diagnosis ... Epithelioid cells → cytokines ... renal failure Clinical ... at the time of diagnosis ... #Sarcoidosis #Diagnosis
Charcot Joint - Neuropathic Arthropathy: Pathogenesis and Clinical findings
 • Impaired joint protection -> abnormal joint
Pathogenesis and Clinical ... • Inflammatory cytokines ... pathophysiology #diagnosis
Immune Reactions and Immunosuppressant Drugs

Glucocorticoids - Inhibition of cytokine synthesis, e.g., IL-1, IL-2
Muromonab-CD3 - Monoclonal antibody
Calcineurin
Inhibition of cytokine ... Inhibition of cytokine