3207 results
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
pro-inflammatory cytokines ... hemophagocytosis and cytokine ... disease • Periodic fever ... - Nonremitting fever ... Syndrome #Diagnosis #Management
Fever vs Hyperthermia
Fever:
 • Regulated in the hypothalamic thermoregulatory center
 • "Set point" raised by prostaglandin
Fever vs Hyperthermia ... Fever: • Regulated ... Endotoxins, Toxins, Cytokines ... BrighamChiefs #Fever ... comparison #diagnosis #management
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
activation and cytokine ... following: • Fever ... Lymphohistiocytosis #diagnosis #management
Renal Cell Carcinoma (RCC) - Diagnosis and Management Summary
Clinical features - Classic triad (flank pain, hematuria,
Diagnosis and Management ... night sweats, fever ... ), Recombinant cytokines ... RCC #Diagnosis #Management
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Pathophysiology: • Cytokine ... Subacute-Acute: • Common: fever ... APML #diagnosis #management
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
pro-inflammatory cytokines ... • Clinical: fever ... Lymphohistiocytosis #diagnosis #management
Sarcoidosis - Diagnosis and Management Summary
Epidemiology
1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
Diagnosis and Management ... Epithelioid cells → cytokines ... General: fever, ... syndrome: ACUTE, fever ... Sarcoidosis #Diagnosis #Management
Blood Transfusion Reactions

Immune Mediated:
 • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
accumulated inflammatory cytokines ... S/sx: Fever, flank ... have drop in Hct, fever ... Sx include: fever ... Transfusion #diagnosis #management
Blood Product Transfusions One Pager Summary
Type and screen - determines blood type and detects in recipient
accumulated inflammatory cytokines ... S/sx: Fever, flank ... have drop in Hct, fever ... Sx include: fever ... Transfusions #diagnosis #management
Hypothermia in Sepsis - Pathophysiology
 • 20% of septic pts → HYPOTHERMIA
 • Increased mortality 62%
proinflammatory cytokines ... anti-inflammatory cytokine