245 results
Immune Reactions and Immunosuppressant Drugs

Glucocorticoids - Inhibition of cytokine synthesis, e.g., IL-1, IL-2
Muromonab-CD3 - Monoclonal antibody
Calcineurin
Inhibition of cytokine ... Inhibition of cytokine ... Pathophysiology #immunology
Type III Hypersensitivity: Pathogenesis and clinical findings
Definition: Small antigen-antibody complexes (produced from normal immune response to
self-antigens are the cause ... Erythematosus (SLE ... antigens are the cause ... HypersensitivityReaction #Allergy #Immunology
Systemic Lupus Erythematosus (SLE): Pathogenesis

 • Genetic factors (Mutations in HLA- DR2/HLA-DR3 genes, complement genes, cytokine
Erythematosus (SLE ... complement genes, cytokine ... of inflammatory cytokines ... Erythematosus #SLE
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
Induced Lupus vs SLE ... 10% of all lupus cases ... drug-dependent) • Immunologic ... Discontinuation of causal ... Cytopenia: Common • Immunologic
Inflammatory mechanism of asthma. 
Airway epithelial cells exposed to activation stimuli, including allergens, viruses, and irritants,
irritants, release cytokines ... release inflammatory cytokines ... of inflammatory cytokines ... #inflammatory #immunology
Eosinophils (Eos) and hypereosinophilia (HE)
Caused by eosinophilopoietic cytokines
Common causes:
 - Drug reaction
 - Helminth infection
 -
hypereosinophilia (HE) Caused ... eosinophilopoietic cytokines ... Common causes: ... disease Rare causes ... Differential #Diagnosis #Causes
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Erythematosus (SLE ... are evocative of SLE ... Cytopenia: Common • Immunologic ... Positive in 60-80% of cases ... management of SLE
Anaphylaxis: Pathogenesis
Anaphylaxis is a Type 1 hypersensitivity reaction
While the primary mechanism of anaphylaxis is mast cell
mediators (e.g. cytokines ... pathophysiology #immunology
SLICC SLE Diagnostic Criteria - Systemic Lupus Erythematosus
Clinical and Immunologic Criteria

CLINICAL CRITERIA
 - ACUTE CUTANEOUS LUPUS
SLICC SLE Diagnostic ... Erythematosus Clinical and Immunologic ... <100,000/MM3) IMMUNOLOGIC ... #Rheumatology #SLE
Causes of Hyperkalemia

Hyperkalemia is caused by excess potassium intake, impaired potassium excretion, or transcellular shifts. The
Causes of Hyperkalemia ... Hyperkalemia is caused ... is rarely the sole ... cause of hyperkalemia ... #Differential #Causes