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Fever vs Hyperthermia Fever: • Regulated in the hypothalamic thermoregulatory center • "Set point" raised by prostaglandin
Endotoxins, Toxins, Cytokines ... rapidly fatal • Causes ... Neuroleptic malignant syndrome ... ; Serotonin syndrome ... Identify underlying cause
Cardiorenal Syndrome (CRS) Types • Type 1 - Acute CRS: Alteration of renal perfusion is the
Cardiorenal Syndrome ... shifts may be in cause ... micro-circulatory dysfunction, cytokine ... #Cardiorenal #Syndrome
Kounis Syndrome Acute coronary syndrome (symptoms such as chest pain relating to reduced blood flow to the
Kounis Syndrome ... Acute coronary syndrome ... to the heart) caused ... of inflammatory cytokines ... Diagnosis #Kounis #Syndrome
Sarcoidosis - Diagnosis and Management Summary Epidemiology 1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
Epithelioid cells → cytokines ... post-sarcoidosis fatigue syndrome ... Specific sarcoidosis syndromes ... symptoms) • Löfgren syndrome ... • Heerfordt syndrome
Hypothermia in Sepsis - Pathophysiology • 20% of septic pts → HYPOTHERMIA • Increased mortality 62%
proinflammatory cytokines ... anti-inflammatory cytokine
Eosinophils (Eos) and hypereosinophilia (HE) Caused by eosinophilopoietic cytokines Common causes: - Drug reaction - Helminth infection -
hypereosinophilia (HE) Caused ... eosinophilopoietic cytokines ... Common causes: ... disease Rare causes ... Differential #Diagnosis #Causes
Causes of Erythema Nodosum - Mnemonic NO cause found in 60% of cases Drugs (antibiotics e.g., sulfonamides, amoxicillin) Oral
Causes of Erythema ... Mnemonic NO cause ... found in 60% of cases ... Sarcoidosis or Lofgren's syndrome ... Nodosum #Mnemonic #Causes
Cutaneous Manifestations of Monoclonal Gammopathy • Extravascular lg Deposits: Systemic amyloidosis, Nodular amyloidosis, Macroglobulinoderma, Follicular hyperkeratotic
Xanthomatosis • Cytokine ... secretion: POEMS syndrome ... , Syndrome Schnitzler ... cutis laxa, TEMPI syndrome
Hyperthermic Syndromes - This table summarizes the similarities and differences between some toxicologic causes of hyperthermic
Hyperthermic Syndromes ... some toxicologic causes ... of hyperthermic syndromes ... • Serotonin syndrome ... #Hyperthermic #Syndromes
Glomerular Diseases - Nephritic and Nephrotic Syndromes Nephritic syndrome—due to GBM disruption. Hypertension. t BUN and creatinine.
and Nephrotic Syndromes ... Nephritic syndrome—due ... RBC casts in urine ... but in severe cases ... Nephritic #Nephrotic #Syndromes
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