6181 results
KSHV Inflammatory Cytokine Syndrome (KICS)

By Dr. Sara Dong @swinndong  via #IDFellowCase
#ID  #Infectious Diseases
KSHV Inflammatory Cytokine ... Syndrome (KICS) ... Differential #Ddx #Diagnosis
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Macrophage Activation Syndrome ... pro-inflammatory cytokines ... hemophagocytosis and cytokine ... Periodic fever syndromes ... #Diagnosis #Management
Streptococcal Toxic Shock Syndrome (STSS)
Complication of invasive GAS disease characterized by shock & MOF → occurs
Streptococcal Toxic Shock Syndrome ... of inflammatory cytokines ... 50% in nec fasc Diagnostic ... #Toxic #Shock #Syndrome ... treatment #management #diagnosis
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome ... Pathophysiology: • Cytokine ... opacities • Diagnosis ... Differentiation #Syndrome ... #APML #diagnosis
KSHV Inflammatory Cytokine Syndrome (KICS)
Working Case Definition for KICS: Requires at least 2 clinical manifestations (from
KSHV Inflammatory Cytokine ... Syndrome (KICS) ... #Inflammatory #Cytokine ... #Syndrome #Kaposi ... #diagnosis #management
Fever vs Hyperthermia
Fever:
 • Regulated in the hypothalamic thermoregulatory center
 • "Set point" raised by prostaglandin
Endotoxins, Toxins, Cytokines ... Neuroleptic malignant syndrome ... ; Serotonin syndrome ... Hyperthermia #comparison #diagnosis
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... activation and cytokine ... Presentation / Diagnosis ... Diagnosis via genetic ... Infection should be diagnosed
Kounis Syndrome

Acute coronary syndrome (symptoms such as chest pain relating to reduced blood flow to the
Kounis Syndrome ... Acute coronary syndrome ... of inflammatory cytokines ... #Diagnosis #Kounis ... #Syndrome #Allergic
Approach to Undifferentiated Shock - OnePager Summary
Shock occurs when there is inadequate blood flow (CO) &
CCB, BB, BRASH syndrome ... fat embolism, cytokine ... release syndrome ... Undifferentiated #Shock #diagnosis
IgA Vasculitis – Henoch Scholein Purpura: Pathogenesis and Clinical Findings

 - Infectious Agents - 50% have
Interleukin 8 (IL8) - cytokine ... nephrotic/nephritic syndrome ... Pathophysiology #Diagnosis