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Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Induced Lupus (DIL ... rash is rare in DIL ... , SCLE-DIL (terbinafine ... for cutaneous DIL ... for cutaneous-DIL
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
Induced Lupus (DIL ... rash is rare in DIL ... , SCLE-DIL (terbinafine ... for cutaneous DIL ... for cutaneous-DIL
Drugs and Classes Associated with DILI and Type of Liver Injury #Medications #Differential #DrugInduced #LiverInjury #Hepatology #Pharmacology
Associated with DILI ... Pharmacology #Causes #DILI
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 Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Liver Injury (DILI ... ) DILI Types: ... disease 6-9 mo after DILI ... • Cholestatic DILI ... EmoryGastroHep #DILI
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Liver Injury (DILI ... Diagnosis Algorithm DILI ... injury, Previous DILI ... hepatitis #DILI
Drug-Induced Liver Injury - Pathophysiology Indirect Idiosyncratic Direct BWH Medicine Chiefs @BrighamChiefs #DILI #DrugInduced #Liver #Injury #Pathophysiology #hepatology
BrighamChiefs #DILI
Lupus Classification Spontaneous Lupus - Cutaneous Lupus Erythematosus (CLE) - Systemic Lupus Erythematosus Drug-Induced Lupus - Drug-Induced
Drug-Induced CLE (SCLE-DIL
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
of SLE versus DIL
Elevated Transaminases / Transaminitis - Differential Diagnosis • Infectious: HAV, HCV, HEV, EBV, HSV, CMV •
• Iatrogenic: DILI
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
(>1000): • DILI
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