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Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Induced Lupus (DIL ... rash is rare in DIL ... , SCLE-DIL (terbinafine ... for cutaneous DIL ... for cutaneous-DIL
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
Induced Lupus (DIL ... rash is rare in DIL ... , SCLE-DIL (terbinafine ... for cutaneous DIL ... for cutaneous-DIL
Lupus Classification Spontaneous Lupus - Cutaneous Lupus Erythematosus (CLE) - Systemic Lupus Erythematosus Drug-Induced Lupus - Drug-Induced
Drug-Induced CLE (SCLE-DIL
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
of SLE versus DIL
Thrombotic Thrombocytopenic Purpura (TTP) vs Disseminated Intravascular Coagulation (DIC) #Diagnosis #TTP #DIC #Comparison #Table #Laboratory #Findings #RebelEM
Intravascular Coagulation (DIC ... Diagnosis #TTP #DIC
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Intravascular Coagulation (DIC ... Manifestations of DIC ... MAHA: TTP/HUS > DIC ... increase > 100mg/dL ... for bleeding #DIC
Drugs and Classes Associated with DILI and Type of Liver Injury #Medications #Differential #DrugInduced #LiverInjury #Hepatology #Pharmacology
Associated with DILI ... Pharmacology #Causes #DILI
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 Liver Disease in Pregnancy Intrahepatic Cholestasis of Pregnancy (ICP) • Onset/Trimester: 25-32 weeks • Typical clinical features:
Bilirubin: <5 mg/dL ... Bilirubin: <5 mg/dL ... DIC • Aminotransferases ... Bilirubin: often <5 mg/dL
Mallet Finger Absence of a fracture does NOT exclude Mallet finger, the extension function of the DIP
function of the DIP ... distal to the DIP ... Swollen and tender DIP ... Extension splint of DIP
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Liver Injury (DILI ... ) DILI Types: ... disease 6-9 mo after DILI ... • Cholestatic DILI ... EmoryGastroHep #DILI
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