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Drug-Induced Liver Injury - Pathophysiology Indirect Idiosyncratic Direct BWH Medicine Chiefs @BrighamChiefs #DILI #DrugInduced #Liver #Injury #Pathophysiology #hepatology
Liver Injury - Pathophysiology ... BrighamChiefs #DILI ... Liver #Injury #Pathophysiology
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Diagnosis and Management ... Liver Injury (DILI ... ) DILI Types: ... • Cholestatic DILI ... differential #Diagnosis #Management
Drugs and Classes Associated with DILI and Type of Liver Injury #Medications #Differential #DrugInduced #LiverInjury #Hepatology #Pharmacology
Associated with DILI ... Pharmacology #Causes #DILI
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 HFNC compared to NIV HFNC: - Comfort - Higher comfort Eating, drinking and speaking less impaired -
preload - P-SILI ... /VILI - Lower risk ... #comparison #management
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Liver Injury (DILI ... Diagnosis Algorithm DILI ... injury, Previous DILI ... hepatitis #DILI
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
Pregnancy (AFLP) Pathophysiology ... 10x ULN), ↑Tbili/Dbili ... Intrahepatic Cholestasis Management ... obgyn #diagnosis #management ... #pathophysiology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Liver Injury (DILI ... Hepatitis Procedures Management ... gastroenterology #management
Amiodarone-Induced Lung Iniurv (AILI) - Timeline Hours to days (peri-procedurally): ARDS Days to months: DAH Weeks: Eosinophilic pneumonia Weeks to
Amiodarone-Induced Lung Iniurv (AILI ... Induced #LungIniurv #AILI
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Induced Lupus (DIL ... rash is rare in DIL ... for cutaneous DIL ... Usual therapeutic management ... rheumatology #diagnosis #management
Elevated Transaminases / Transaminitis - Differential Diagnosis • Infectious: HAV, HCV, HEV, EBV, HSV, CMV •
• Iatrogenic: DILI
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