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Diffuse large B cell lymphoma (DLBCL) - Management and Treatment Algorithm

By Matthew Ho, MD PhD @MatthewHoMD

#Diffuse
Diffuse large B ... cell lymphoma (DLBCL ... Management and Treatment ... MatthewHoMD #Diffuse ... Bcell #lymphoma #DLBCL
Pericarditis can be seen on EKG with diffuse ST elevations without reciprocal changes along with diffuse
seen on EKG with diffuse ... changes along with diffuse ... First line treatment
Lymphoma Classification
Non-Hodgkin - T-Cell Lymphoma
Non-Hodgkin - B-Cell Lymphomas:
 • Highly Aggressive - Burkitt, Aggresive
 • Aggressive
• Aggressive - DLBCL
Differential diagnosis
The table summarizes the most common diseases, that present with consolidation.
Chronic diseases are indicated in
distribution: - Diffuse ... pneumoniae may become diffuse ... respond to the treatment ... they may become diffuse ... Consolidation #Lobar #Diffuse
Stroke - Differential Diagnosis Algorithm and Management
Hemorrhagic:
 • Intracerebral: HTN, Cerebral Amyloid Angiopathy, Trauma, Bleeding Diathesis,
: Hypotension, Diffuse ... management #neurology #treatment
Severe Asthma Exacerbation
Signs of a Severe Asthma Exacerbation:
 • Vitals: ↑HR ↑RR ↓SpO2
 • High work
sentences • Diffuse ... of baseline Treatments ... mechanical #management #treatment
Algorithm for Diagnosis of the Vesiculobullous Rash

Febrile, Diffuse Distribution:
 - Varicella,  Smallpox,  Disseminated, Gonococcal,
Rash Febrile, Diffuse ... Disease Afebrile Diffuse
Causes of Diffuse and Localized Lymphadenopathy - Differential Diagnosis Algorithm
 • Reactive (Inflammatory / Infectious)
 •
Causes of Diffuse ... Metastatic) #Diffuse
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
B-cell lymphoma (DLBCL ... Unknown cause Treatment ... diagnosis #management #treatment
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm
Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
lymphadenopathy more diffuse ... Responsive to Treatment ... growth, response to treatment