8 results
Oral anticoagulant dosing and bridging for VTE

- Dr. Joseph Shatzel @Clotmaster 

#VTE #DOAC #Bridging #Dosing #Oral
Oral anticoagulant ... Clotmaster #VTE #DOAC ... #Oral #Anticoagulant ... #Anticoagulation ... #Rivaroxaban #Edoxaban
Pharmacokinetic Characteristics and Primary Routes of Clearance of Oral Anticoagulant Agents

Warfarin - 100% Hepatic, 0% Renal
Apixaban
Anticoagulant Agents ... Hepatic, 35% Renal #DOAC ... #NOAC #Metabolism ... #Pharmacology # ... #anticoagulation
DOAC: Cheat Sheet - Atrial Fibrillation, VTE Prophylaxis, VTE and Renal Dosing

Renal Dosing:
Apixaban (25% renal clearance):
DOAC: Cheat Sheet ... AFib: CrCl 15-50 ... @Bloodman #DOAC ... #Dabigatran #Edoxaban ... #NOAC
DOAC Reversal
Emergency surgery or urgent procedure
Stop anticoagulant treatment; volume resuscitation and transfusion as needed
Antidotes:
 • Apixaban,
DOAC Reversal Emergency ... or Rivaroxaban ... not available #DOAC ... #Reversal #NOAC ... #Oral #anticoagulant
Oral Anticoagulation Management Cheat Sheet: Warfarin, Apixaban, Dabigatran, Rivaroxaban
 - Mechanism of Action
 - Routine Blood
Oral Anticoagulation ... , Rivaroxaban ... #Anticoagulant ... #DOAC #Management ... #Table #Pharmacology
Heparin, Fondaparinux, and Novel Oral Anticoagulants - Pathophysiology

Anticoagulation with parenteral (intravenous or subcutaneous) and oral anticoagulants
accelerates the bridging ... : A new oral anticoagulant ... Heparins #LMWH #UFH #DOAC ... #Dabigatran #Apixaban ... #NOAC #Mechanism
Perioperative Management of DOACs
Problem:
 ✖ Each year approximately 250,000 patients on chronic anticoagulation in North America
direct acting oral ... determine timing of DOAC ... ) • Apixaban, Edoxaban ... , Rivaroxaban (anti-XA ... postoperative #DOAC
Atrial Fibrillation (A-Fib) Summary

Symptoms:
• Palpitations, light-headedness, dizziness, dyspnea, exercise intolerance, chest pain, near-syncope, syncope.

Why?
Cardiac:
	• Valvular heart
Drugs/toxins • Metabolic ... typically needed • DOACs ... Xa inhibitors (rivaroxaban ... , apixaban, edoxaban ... #diagnosis #management