10 results
Oral anticoagulant dosing and bridging for VTE

- Dr. Joseph Shatzel @Clotmaster 

#VTE #DOAC #Bridging #Dosing #Oral
#DOAC #Bridging ... Anticoagulant #Anticoagulation ... Dabigatran #Apixaban #Rivaroxaban ... #Edoxaban #Loading ... #DVT #Pharmacology
DOAC: Cheat Sheet - Atrial Fibrillation, VTE Prophylaxis, VTE and Renal Dosing

Renal Dosing:
Apixaban (25% renal clearance):
- Atrial Fibrillation ... if CrCl < 50) Edoxaban ... @Bloodman #DOAC ... OralAnticoagulant #Anticoagulation ... #Hematology #Pharmacology
Patient risk stratification algorithm for the treatment of cancer-associated thrombosis.

Currently, edoxaban and rivaroxaban are the only
for the treatment ... Currently, edoxaban ... and rivaroxaban ... #DOAC #VTE #Malignancy ... #Anticoagulation
Xa Inhibitors - Apixaban and Rivaroxaban 
Oral Xa inhibitors are recommended by CHEST as first-line for
patients with VTE ... treatment or Atrial ... Fibrillation requiring anticoagulation ... indications and edoxaban ... #Dosing #Pharmacology
Choice of anticoagulant for treatment of pulmonary embolism
 • Malignancy - LMWH
 • To avoid parenteral
anticoagulant for treatment ... ; edoxaban; VKA ... #decisionaid #vte ... #anticoagulation ... #pharmacology
Heparin, Fondaparinux, and Novel Oral Anticoagulants - Pathophysiology

Anticoagulation with parenteral (intravenous or subcutaneous) and oral anticoagulants
Pathophysiology Anticoagulation ... the mainstay of VTE ... accelerates the bridging ... #Pharmacology #Pathophysiology ... Heparins #LMWH #UFH #DOAC
Perioperative Management of DOACs
Problem:
 ✖ Each year approximately 250,000 patients on chronic anticoagulation in North America
patients on chronic anticoagulation ... interruption per treatment ... ) • Apixaban, Edoxaban ... , Rivaroxaban (anti-XA ... #pharmacology #
Treatment algorithm for VTE in Malignancy

(A) Suggested treatment algorithm for symptomatic and incidental DVT or PE
Treatment algorithm ... **Edoxaban is initiated ... DOAC, direct oral ... #DOAC #VTE #Malignancy ... #Anticoagulation
Atrial Fibrillation (A-Fib) Summary

Symptoms:
• Palpitations, light-headedness, dizziness, dyspnea, exercise intolerance, chest pain, near-syncope, syncope.

Why?
Cardiac:
	• Valvular heart
β-blocker or CCB Anticoagulation ... typically needed • DOACs ... Xa inhibitors (rivaroxaban ... , apixaban, edoxaban ... diagnosis #management #cardiology
Peripartum Cardiomyopathy - Summary
1. Definition
 • Towards the end of pregnancy to 5 months postpartum
Avoid Warfarin and DOAC ... suggest prophylactic anticoagulation ... Serial TTE and close ... diagnosis #management #cardiology ... #treatment