11 results
Switching Between Anticoagulants and DOACs
VKA, Dabigatran, Rivaroxaban, Apixaban, Edoxaban, Betrixaban, DOAC, Parenteral anticoagulant

DOI: 10.1161/JAHA.120.017559

#Anticoagulants #DOACs #anticoagulation
Switching Between Anticoagulants ... and DOACs VKA, ... , Apixaban, Edoxaban ... , Betrixaban, DOAC ... #DOACs #anticoagulation
Oral anticoagulant dosing and bridging for VTE

- Dr. Joseph Shatzel @Clotmaster 

#VTE #DOAC #Bridging #Dosing #Oral
Oral anticoagulant ... #DOAC #Bridging ... #Dosing #Oral #Anticoagulant ... #Anticoagulation ... #Dabigatran #Apixaban
Patient risk stratification algorithm for the treatment of cancer-associated thrombosis.

Currently, edoxaban and rivaroxaban are the only
direct-acting oral anticoagulants ... (DOACs) with randomized ... filtration rate; DOAC ... direct-acting oral anticoagulant ... #DOAC #VTE #Malignancy
Anticoagulants Common Reversal Agents
 - Warfarin (Coumadin) → Vitamin K (Phytonadione), 4-factor PCC (Kcentra)
 - Heparin/LMWH
Anticoagulants Common ... Protamine sulfate - Dabigatran ... (Praxbind) - Apixaban ... #doac #noac #pharmacology ... #hematology #reversal
Pharmacokinetic Characteristics and Primary Routes of Clearance of Oral Anticoagulant Agents

Warfarin - 100% Hepatic, 0% Renal
Apixaban
Clearance of Oral Anticoagulant ... Hepatic, 0% Renal Apixaban ... Hepatic, 80% Renal Edoxaban ... Hepatic, 35% Renal #DOAC ... #NOAC #Metabolism
DOAC: Cheat Sheet - Atrial Fibrillation, VTE Prophylaxis, VTE and Renal Dosing

Renal Dosing:
Apixaban (25% renal clearance):
DOAC: Cheat Sheet ... - Atrial Fibrillation ... @Bloodman #DOAC ... #Dabigatran #Edoxaban ... #NOAC
DOAC Reversal
Emergency surgery or urgent procedure
Stop anticoagulant treatment; volume resuscitation and transfusion as needed
Antidotes:
 • Apixaban,
DOAC Reversal Emergency ... procedure Stop anticoagulant ... not available #DOAC ... #Reversal #NOAC ... #Oral #anticoagulant
Heparin, Fondaparinux, and Novel Oral Anticoagulants - Pathophysiology

Anticoagulation with parenteral (intravenous or subcutaneous) and oral anticoagulants
and Novel Oral Anticoagulants ... or a new oral anticoagulant ... Heparins #LMWH #UFH #DOAC ... #Dabigatran #Apixaban ... #Fondaparinux #NOAC
Perioperative Management of DOACs
Problem:
 ✖ Each year approximately 250,000 patients on chronic anticoagulation in North America
Management of DOACs ... direct acting oral anticoagulants ... to assess for anticoagulant ... determine timing of DOAC ... postoperative #DOAC
Effect of Direct Oral Anticoagulants on Hemostatic Tests
Horizontal bars correspond to the approximate range of detectability
of Direct Oral Anticoagulants ... and edoxaban. ... thrombin time #doac ... #noac #anticoagulation ... #hematology #laboratory