11 results
Switching Between Anticoagulants and DOACs
VKA, Dabigatran, Rivaroxaban, Apixaban, Edoxaban, Betrixaban, DOAC, Parenteral anticoagulant

DOI: 10.1161/JAHA.120.017559

#Anticoagulants #DOACs #anticoagulation
Switching Between Anticoagulants ... Dabigatran, Rivaroxaban ... , Betrixaban, DOAC ... , Parenteral anticoagulant ... #DOACs #anticoagulation
Oral anticoagulant dosing and bridging for VTE

- Dr. Joseph Shatzel @Clotmaster 

#VTE #DOAC #Bridging #Dosing #Oral
Oral anticoagulant ... #DOAC #Bridging ... #Dosing #Oral #Anticoagulant ... #Rivaroxaban #Edoxaban ... #Hematology
Anticoagulants Common Reversal Agents
 - Warfarin (Coumadin) → Vitamin K (Phytonadione), 4-factor PCC (Kcentra)
 - Heparin/LMWH
Anticoagulants Common ... Protamine sulfate - Dabigatran ... (Lixiana), Rivaroxaban ... #doac #noac #pharmacology ... #hematology #reversal
Pharmacokinetic Characteristics and Primary Routes of Clearance of Oral Anticoagulant Agents

Warfarin - 100% Hepatic, 0% Renal
Apixaban
Clearance of Oral Anticoagulant ... Hepatic, 80% Renal Edoxaban ... Hepatic, 35% Renal #DOAC ... #NOAC #Metabolism ... #Pharmacology #
Heparin, Fondaparinux, and Novel Oral Anticoagulants - Pathophysiology

Anticoagulation with parenteral (intravenous or subcutaneous) and oral anticoagulants
and Novel Oral Anticoagulants ... or a new oral anticoagulant ... #Pharmacology #Pathophysiology ... Heparins #LMWH #UFH #DOAC ... #NOAC #Mechanism
DOAC: Cheat Sheet - Atrial Fibrillation, VTE Prophylaxis, VTE and Renal Dosing

Renal Dosing:
Apixaban (25% renal clearance):
DOAC: Cheat Sheet ... @Bloodman #DOAC ... #Hematology #Pharmacology ... #Dabigatran #Edoxaban ... #NOAC
Patient risk stratification algorithm for the treatment of cancer-associated thrombosis.

Currently, edoxaban and rivaroxaban are the only
and rivaroxaban ... direct-acting oral anticoagulants ... filtration rate; DOAC ... direct-acting oral anticoagulant ... #DOAC #VTE #Malignancy
DOAC Reversal
Emergency surgery or urgent procedure
Stop anticoagulant treatment; volume resuscitation and transfusion as needed
Antidotes:
 • Apixaban,
DOAC Reversal Emergency ... procedure Stop anticoagulant ... not available #DOAC ... #Reversal #NOAC ... #Oral #anticoagulant
Perioperative Management of DOACs
Problem:
 ✖ Each year approximately 250,000 patients on chronic anticoagulation in North America
direct acting oral anticoagulants ... to assess for anticoagulant ... determine timing of DOAC ... , Rivaroxaban (anti-XA ... postoperative #DOAC
Effect of Direct Oral Anticoagulants on Hemostatic Tests
Horizontal bars correspond to the approximate range of detectability
of Direct Oral Anticoagulants ... and edoxaban. ... thrombin time #doac ... #noac #anticoagulation ... #hematology #laboratory