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Switching Between Anticoagulants and DOACs VKA, Dabigatran, Rivaroxaban, Apixaban, Edoxaban, Betrixaban, DOAC, Parenteral anticoagulant DOI: 10.1161/JAHA.120.017559 #Anticoagulants #DOACs #anticoagulation
Anticoagulants and DOACs ... VKA, Dabigatran ... Edoxaban, Betrixaban, DOAC ... Anticoagulants #DOACs ... anticoagulation #Switching #hematology
NOAC / DOAC Pharmacology and Prescribing Cheat Sheet Novel (or Direct) Oral Anti-Coagulants • Rivaroxaban • Apixaban
NOAC / DOAC Pharmacology ... • Apixaban • Dabigatran ... #NOAC #DOAC #Pharmacology ... #Prescribing #hematology
Oral anticoagulant dosing and bridging for VTE - Dr. Joseph Shatzel @Clotmaster #VTE #DOAC #Bridging #Dosing #Oral
Clotmaster #VTE #DOAC ... Anticoagulation #Dabigatran ... #Pharmacology #Hematology
Anticoagulants Common Reversal Agents - Warfarin (Coumadin) → Vitamin K (Phytonadione), 4-factor PCC (Kcentra) - Heparin/LMWH
Protamine sulfate - Dabigatran ... anticoagulation #doac ... #noac #pharmacology ... #hematology #reversal
DOAC: Cheat Sheet - Atrial Fibrillation, VTE Prophylaxis, VTE and Renal Dosing Renal Dosing: Apixaban (25% renal clearance):
DOAC: Cheat Sheet ... patients 5mg bid Dabigatran ... @Bloodman #DOAC ... Anticoagulation #Hematology ... #Rivaroxaban #Dabigatran
(DOAC interactions) Cancer-treatment specific inducers (↑) and inhibitors (↓) of cytochrome p450 CYP3A4 and P-glycoprotein. DOACs are substrates
(DOAC interactions ... DOACs are substrates ... metabolization of DOACs ... Dabigatran has moderate ... Chemotherapy #Oncology #Hematology
DOAC Reversal Emergency surgery or urgent procedure Stop anticoagulant treatment; volume resuscitation and transfusion as needed Antidotes: • Apixaban,
DOAC Reversal Emergency ... modified factor Xa • Dabigatran ... not available #DOAC ... #Reversal #NOAC ... anticoagulant #hematology
Effect of Direct Oral Anticoagulants on Hemostatic Tests Horizontal bars correspond to the approximate range of detectability
concentrations of dabigatran ... thrombin time #doac ... #noac #anticoagulation ... #hematology #laboratory
Warfarin and DOAC Pharmacology Warfarin - Dabigatran - Rivaroxaban - Apixaban - Edoxaban Target - Prodrug - Bioavailability
Warfarin and DOAC ... Pharmacology Warfarin - Dabigatran ... h) #Warfarin #DOAC ... #Pharmacology #NOAC ... comparison #table #dabigatran
Pharmacokinetic Characteristics and Primary Routes of Clearance of Oral Anticoagulant Agents Warfarin - 100% Hepatic, 0% Renal Apixaban
Hepatic, 25% Renal Dabigatran ... Hepatic, 35% Renal #DOAC ... #NOAC #Metabolism
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