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Mechanism of Action for Common Diabetes Medications • SGLT2i (Dapagliflozin) • TZD (Pioglitazone) • Biguanides (Metformin)
GLP-1 Receptor Agonists ... • DPP4i / Gliptins ... #pharmacology #pathophysiology
DPP-4 Inhibitors - Pharmacology Summary Mechanisms of Action: Inhibits DPP-4 (dipeptidyl peptidase 4), which normally inactivates GLP-1
DPP-4 Inhibitors ... Action: Inhibits DPP ... GLP-I receptor agonist ... EricsMedicalLectures/featured #DPP4
Oral Hypoglycemics in Diabetes Management 1 INSULIN SENSITIZER • TZD -
- PPAR gamma agonist ... AGENTS • GLP-1 agonists ... (Adlyxin) • DPP ... by inhibiting DPP
Diabetes Medications Summary Table Insulin Lifestyle modifications Metformin Sulfonylureas GLP-1 receptor agonists - ↓ major adverse CV events TZDs DPP-4 inhibitors SGLT2 inhibitors -
GLP-1 receptor agonists ... events TZDs DPP
Diabetes Combination Tablets - Estimated A1c Lowering Metformin + DPP4 • Janumet (metformin + sitagliptin) •
Metformin + DPP4 ... dapagliflozin) Dpp4
DPP4 Inhibitors - Normal and Renal Dosing Increase Incretins (GLP-I & GIP) -> Stimulates Insulin, Inhibits Glucagon
DPP4 Inhibitors ... linagliptin) 5 mg DPP4 ... lower dose of a DPP4 ... /ambcarerx #DPP4
Classification of Adrenergic Receptor Agonists (sympathomymetics) #Adrenergic #Receptor #Agonists #sympathomymetics #Classification #Pharmacology
Adrenergic Receptor Agonists ... Adrenergic #Receptor #Agonists
GLP-1 Agonists Adlyxin (Lixisenatide) Daily Bydureon (Exenatide ER) Weekly Ozempic (Semaglutide) Weekly Trulicity (Dulaglutide) Weekly Victoza (Liraglutide) Daily
GLP-1 Agonists ... Daily GLP-1 Agonists ... very similar to DPP4s ... #GLP1 #Agonists
Opioid Use Disorder Medications - Pharmacokinetics Buprenorphine is a partial mu-opioid receptor agonist with low intrinsic activity,
mu-opioid receptor agonist ... displacing full agonists ... As a partial agonist ... However, full agonists ... As a partial agonist
Rybelsus (oral semaglutide) - First Oral GLP-1 Agonist Dosing: 3 mg daily x 30 days, then 7 mg
First Oral GLP-1 Agonist ... only) oral GLP1 agonist ... injectable GLP1 agonists ... GLP1 agonists are ... empagliflozin and DPP4
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