24 results
Acute promyelocytic leukemia (blood). Typical morphologic features are bilobed ("butterfly") nuclei with dispersed chromatin, subtle to
overt cytoplasmic granules ... I see all of these ... promyelocytic #leukemia #APL ... #APML #Pathology ... #Hematology #Clinical
Hypereosinophilia and Hypereosinophilic Syndrome

 • Secondary Hypereosinophilic Syndrome
 • Clinically Relevant HES Variants
 • When to
Hypereosinophilic Syndrome ... • Clinically ... suspect underlying hematologic ... disorders • Diagnosis ... #HES #Hematology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Kasabach-Merritt syndrome ... - PNH - APLS ... Gardner-Diamond syndrome ... Differential #Diagnosis #hematology ... #nonpalpable #dermatology
Staphylococcal Scalded Skin Syndrome (SSSS)

A 5-year-old girl presents to the ED with a rash that started
Staphylococcal Scalded Skin Syndrome ... Scalded #Skin #Syndrome ... #SSSS #Clinical ... #Photo #Peds #Pediatrics ... #Dermatology
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
, CML, AML, APML ... develop leukostasis syndrome ... distinctive primary granules ... • Tumor lysis syndrome ... #Leukemia #Hematology
Inherited Qualitative Platelet Defects
Bernard-Soulier Syndrome
 • Defect of adhesion due to a lack of GP Ib/IX/V
Bernard-Soulier Syndrome ... MYH9-Related Disorder ... Grey Platelet Syndrome ... of platelet α-granules ... differential #diagnosis #hematology
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE) Clinical ... Demyelinating Syndrome ... Headache, Movement disorders ... , Seizure disorders ... (for secondary APS
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis

Neurologic-Centered:
 (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
Gammopathy of Clinical ... Features: POEMS, AL ... capillary leak syndrome ... • Schnitzler syndrome ... Differential #Diagnosis #hematology
SAPHO Syndrome Summary

What?
SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
chronic inflammatory disorder ... Autoinflammatory disorder ... Rheumatic pain Clinical ... Diagnosis: • A clinical ... diagnosis #management #Dermatology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
lymphoproliferative disorder ... Cold Agglutinin Syndrome ... infection, autoimmune disorder ... Viral Infection Clinical ... hemolytic #anemia #hematology