11 results
Acute promyelocytic leukemia (blood). Typical morphologic features are bilobed ("butterfly") nuclei with dispersed chromatin, subtle to
overt cytoplasmic granules ... I see all of these ... promyelocytic #leukemia #APL ... #APML #Pathology ... #Hematology #Clinical
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Manifestations of Systemic ... Erythematosus (SLE ... ) Clinical Manifestations ... , Seizure disorders ... (for secondary APS
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
likely it will be clinically ... erythematosus (SLE ... erythematosus (SLE ... Lymphoproliferative Disorders ... ANA #patterns #rheumatology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... ) Suspect: Clinical ... lymphoproliferative syndrome Clinical ... • CAD APLA/LAC ... vein thrombosis Hematologic
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus
Clinical Domains:
 • Constitutional domain: Fever
 • Cutaneous domain: Non-scarring
Classification Criteria for Systemic ... Erythematosus Clinical ... Anticardiolipin IgG > 40 GPL ... Classification #Criteria #SLE ... #Systemic #Lupus
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
activate the immune system ... Syndrome: • Clinical ... diseases: - 10% SLE ... (e.g. systemic ... erythematosus (SLE
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
Epidemiology: -10% of all ... to 1:1 F:M • Clinical ... months to years) Systemic ... 40, F:M 9:1 • Clinical ... comparison #table #rheumatology
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases

• Septic arthritis - Gram stain and culture of
Rheumatology Workup ... affected joint • Systemic ... Screening Tests for All ... metabolic or endocrine disorders ... ANA and RF (if clinical
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
rendering the immune system ... Orange or Hep C Clinical ... ’s CLL Scoring system ... lymphoproliferative disorders ... workup #oncology #hematology
Helpful Clinical Features in Evaluating Bleeding Disorders
Age of onset
 • Neonate - in 20% of haemophilias,
Helpful Clinical ... relatives (if all ... • Presence of systemic ... #History #peds ... pediatrics #diagnosis #hematology