12 results
Acromegaly 
Caused by over-secretion of growth hormone (GH) from the pituitary gland. 
The condition is rare
Acromegaly Caused ... (GH) from the pituitary ... #Acromegaly #Signs ... Symptoms #Diagnosis #Endocrinology
Clinical Effects of Large and Small Pituitary Tumours
Local complications - Headache, Visual field defect, Disconnection hyperprolactinaemia,
Clinical Effects ... , Visual field defect ... Hypogonadism • Acromegaly ... #Tumors #Signs ... Symptoms #Diagnosis #Endocrinology
Acromegaly - Diagnosis and Management Summary - GrepMed Handbook 

Clinical Presentation: 
 • Classic Acromegaly: frontal
Macroadenoma direct effects ... - GH-secreting pituitary ... (Up to 30% of pituitary ... • Pituitary ... Diagnosis #Management #Endocrinology
Congenital Adrenal Hyperplasia - 21-Hydroxylase Deficiency - Signs and Symptoms
 • Brain: Androgenization effects, Glucocorticoid effects,
Hydroxylase Deficiency - Signs ... Glucocorticoid effects ... • Hypothalamic–Pituitary ... Hydroxylase #Deficiency #Signs ... Symptoms #diagnosis #endocrinology
Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
activates lipolysis Signs ... - Giantism or acromegaly ... #FeedbackLoop #endocrinology ... pathophysiology #pituitary
Pituitary Mass Effects - Pathogenesis and Clinical Findings
 • Pituitary turnors are almost always a benign
Pituitary Mass Effects ... Pituitary adenomas ... secreting tumors can ... Signs / Symptoms ... #SideEffects #endocrinology
Primary Hyperthyroidism - Pathogenesis and Clinical Findings

Note: Although rare, gestational diseases can lead to thyrotoxicosis due
gestational diseases can ... production by the pituitary ... can also occur. ... Signs/Symptoms: ... Hyperthyroidism #endocrinology
Approach to Thyroid Function Tests in the Evaluation of Hyperthyroidism
 • Low TSH, Low normal T4
Can repeat labs ... Hyperthyroidism → Signs ... Hyperthyroidism → MRI Pituitary ... algorithm #diagnosis #endocrinology
First Generation Anti-Psychotics: Mechanisms and Side Effects
Typical/Conventional Anti-Psychotics - Examples: Haloperidol, Chlorpromazine

ACh M1 antagonist - Block
Mechanisms and Side Effects ... Chlorpromazine ACh ... Block action of ACh ... Hypothalamus -> Pituitary ... #SideEffects #pharmacology
Primary Adrenal Insufficiency:
 • ACTH stimulation test - Synthetic ACTH does not stimulate cortisol secretion because
production • CRH ... Serum tests that detect ... hypothalamus or pituitary ... deficiency (from the pituitary ... diagnosis #testing #endocrinology