Clinical Effects of Large and Small Pituitary Tumours Local complications - Headache, Visual field defect, Disconnection hyperprolactinaemia, Diplopia (cavernous sinus involvement), Acute infarction/expansion (pituitary apoplexy) Hormone excess • Hyperprolactinaemia - Galactorrhoea, Amenorrhoea, Hypogonadism • Acromegaly - Headache, Sweating, Change in shoe and ring size • Cushing's disease - Weight gain, Bruising, Myopathy, Hypertension, Striae, Depression Hypopituitarism • Growth hormone - Lethargy • Gonadotrophins - Lethargy, Loss of libido, Hair loss, Amenorrhoea • ACTH - Lethargy, Postural hypotension, Pallor, Hair loss • TSH - Lethargy • Vasopressin (ADH) (usually post-surgical) - Thirst and polyuria #Pituitary #Tumors #Signs #Symptoms #Diagnosis #Endocrinology
