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diagnosis oncology agglutinin atlas bloodcell chronic extravascular hemolysis intravascular leukemia lymphomas lymphoproliferative management mds mentzerindex microscopy morphology myelodysplasia myelodysplastic nomenclature
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Red Blood Cell ( ... (sometimes) Macrocytic ... Unstable hemoglobin disorders ... hemolytic anemia ... #diagnosis #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
) (e.g. lupus, CLL ... , lymphoma, idiopathic ... lymphoproliferative disorders ... #differential # ... diagnosis #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
with no early symptoms ... cells can indicate disease ... lymphoproliferative disorders ... • Neutropenia, anemia ... #oncology #hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• Autoimmune disorders ... ingestion • B symptoms ... of cases) Classification ... Lymphoma Workup ... #hematology #oncology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
- Lymphoid Malignancy ... anemia • Cold ... younger pts) Differential ... #hemolytic #anemia ... #hematology #diagnosis
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Disorders - Differential ... Hodgkin Lymphoma ... pattern of spread, B symptoms ... #Classification ... pathophysiology #Hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Agglutination - Cold ... Consider RBC membrane disorder ... #Anemia #Differential ... #workup #hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- Differential ... plateletcount), peripheral blood ... pylori test (GI symptoms ... changes), high MCV anemia ... #Workup #hematology
Hematology Algorithms Anemia is described as a reduction in the proportion of the red blood cells.
Hematology Algorithms ... proportion of the red blood ... experience some symptoms ... three peripheral blood ... These causes could
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
caused by blood ... age 70 years Symptoms ... cell count (anemia ... differential • ... Syndromes #diagnosis #hematology
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