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hematology differential algorithm intravascular common cvid dic disseminated extravascular hemolysis hypogammaglobulinemia immunodeficiency immunology leukemia nonpalpable normocytic oncology palpable petechiae petechial
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... intravascular coagulation ... thrombocytopenic purpura ... usually IgM) (e.g. primary ... #hematology #anemia
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Diagnosis Framework ... /Quantity: • Primary ... : ITP • Secondary ... DIC/TTP/HUS - Hemolytic ... anemia - Splenomegaly
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Causes of Anemia ... - Differential Diagnosis ... Reticulocytosis • Primary ... Hypersplenism • Secondary ... #Hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Causes of Thrombocytosis ... malignancies • Anemia ... iron deficiency, hemolysis ... Post-splenectomy Primary ... #Causes #hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Treatment: • Treat primary ... cause • Correct ... #diagnosis #causes ... #treatment #management ... #hematology
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
Causes of Petechial ... Abnormalities in primary ... or secondary hemostasis ... Complete blood count coagulation ... #dermatology #physicalexam
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
infection risk secondary ... and autoimmune hemolytic ... anemia) • Systemic ... DDX - Other causes ... #diagnosis #management
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
activity • ↓ LAP Score ... - infiltrates (anemia ... + distinctive primary ... bone marrow and secondary ... #Oncology #Diagnosis
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